Merck

G1269

Sigma-Aldrich

Gly-Arg-Gly-Asp-Ser-Pro-Lys

≥97% (HPLC)

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别名:
GRGDSPK
Empirical Formula (Hill Notation):
C28H49N11O11
分子量:
715.76
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

生物来源

human

质量水平

检测方案

≥97% (HPLC)

形式

powder

technique(s)

blocking: suitable
ligand binding assay: suitable

储存温度

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O

InChI

1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1

InChI key

ZRVZOBGMZWVJOS-VMXHOPILSA-N

Gene Information

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此商品
G4391A9041A8052
Gly-Arg-Gly-Asp-Ser-Pro-Lys ≥97% (HPLC)

Sigma-Aldrich

G1269

Gly-Arg-Gly-Asp-Ser-Pro-Lys

Gly-Arg-Gly-Asp-Ser ≥97% (HPLC)

Sigma-Aldrich

G4391

Gly-Arg-Gly-Asp-Ser

Arg-Gly-Asp ≥97% (TLC)

Sigma-Aldrich

A8052

Arg-Gly-Asp

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (TLC)

form

powder

form

powder

form

powder

form

powder

technique(s)

blocking: suitable, ligand binding assay: suitable

technique(s)

blocking: suitable, cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | stem cell: suitable

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

一般描述

Gly-Arg-Gly-Asp-Ser-Pro-Lys是一种RGD肽。作为胞外基质(ECM)蛋白中的天然RGD肽,参与促进整合素介导的细胞与基质蛋白的黏附。RGD肽在细胞黏附蛋白(如纤连蛋白和玻连蛋白)中以重复形式存在。这种三肽被细胞中特定的整合素(如β1、β3和β5亚基)识别,存在于细胞表面,通过粘着斑(FA)复合物与肌动蛋白丝关联。

应用

Gly-Arg-Gly-Asp-Ser-Pro-Lys(RGD肽)已用于
  • 作为抑制肽抑制整合素和纤连蛋白的结合
  • 通过猪滋养外胚层粘附实验研究TGFβ(转化生长因子)对细胞粘附的影响
  • 培养MC3T3-E1成骨细胞,通过AFM(原子力显微镜)检测其对细胞粘附的影响作用
  • 制备RGD.Flt23k.NR纳米颗粒
  • 确定RGD-整合素连接在细胞粘附过程中的参与

生化/生理作用

结合整合素的纤连蛋白类似物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Pierre-Henri Puech et al.
Journal of cell science, 118(Pt 18), 4199-4206 (2005-09-13)
During vertebrate gastrulation, progenitor cells of different germ layers acquire specific adhesive properties that contribute to germ layer formation and separation. Wnt signals have been suggested to function in this process by modulating the different levels of adhesion between the
J Holland et al.
Biomaterials, 17(22), 2147-2156 (1996-11-01)
A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)
Christine Selhuber-Unkel et al.
Biophysical journal, 95(11), 5424-5431 (2008-08-12)
We have studied the initial phase of cell adhesion as a function of the lateral organization of individual integrin molecules with single-cell force microscopy. Nanostructures, consisting of hexagonally ordered gold dots, were prepared with diblock-copolymer micelle lithography and functionalized with
Kazuyuki Onodera et al.
European journal of cell biology, 84(1), 45-58 (2005-02-24)
Biomechanical forces are major epigenetic factors that determine the form and differentiation of skeletal tissues, and may be transduced through cell adhesion to the intracellular biochemical signaling pathway. To test the hypothesis that stepwise stretching is translated to molecular signals
Yang Kyung Cho et al.
Investigative ophthalmology & visual science, 53(4), 2328-2336 (2012-03-20)
To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the emulsion solvent evaporation

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