Merck

G5792

SAFC

L-谷氨酰胺

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别名:
(S)-2,5-二氨基-5-氧代戊酸, L-谷氨酸-5-酰胺, 左谷酰胺
线性分子式:
H2NCOCH2CH2CH(NH2)CO2H
CAS号:
分子量:
146.14
Beilstein:
1723797
EC 号:
MDL编号:
eCl@ss:
32160406
NACRES:
NA.26

生物来源

non-animal source

质量水平

检测方案

≥99%

形式

powder

manufacturer/tradename

Ajinomoto

technique(s)

cell culture | mammalian: suitable

杂质

endotoxin, heavy metals, residual solvents, tested

mp

185 °C (dec.) (lit.)

溶解性

H2O: 25 mg/mL

application(s)

pharmaceutical (small molecule)

异质活性

cytotoxicity, tested

SMILES string

N[C@@H](CCC(N)=O)C(O)=O

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1

InChI key

ZDXPYRJPNDTMRX-VKHMYHEASA-N

Gene Information

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此商品
49419G8540G6392
L-Glutamine

SAFC

G5792

L-谷氨酰胺

-
L-Glutamine BioUltra, ≥99.5% (NT)

Sigma-Aldrich

49419

L-谷氨酰胺

Premium Grade
L-Glutamine meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source

Sigma-Aldrich

G8540

L-谷氨酰胺

-
L-Glutamine γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

G6392

L-谷氨酰胺

-
form

powder

form

powder

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, residual solvents, tested

impurities

insoluble matter, passes filter test, ≤0.5% foreign amino acids

impurities

endotoxin, tested

impurities

endotoxin, tested

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

solubility

H2O: 25 mg/mL

solubility

H2O: 0.1 M at 20 °C, clear, colorless

solubility

H2O: 25 mg/mL

solubility

H2O: 10 mL/vial, clear to slightly hazy

一般描述

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我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。

M-Clarity Program

我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

应用

L-谷氨酰胺是一种必需氨基酸,作为细胞培养过程中主要的能量来源而成为培养基的重要组分。L-谷氨酰胺在干粉及冷冻溶液的状态下极为稳定。然而,L-谷氨酰胺在液体培养基或储存溶液中均会相对较快的降解。最佳的细胞表现通常需要在使用前向培养基中添加补充剂。

生化/生理作用

L-谷氨酰胺是一种必需氨基酸,作为细胞培养过程中主要的能量来源而成为培养基的重要组分。L-谷氨酰胺在干粉及冷冻溶液的状态下极为稳定。然而,L-谷氨酰胺在液体培养基或储存溶液中均会相对较快的降解。最佳的细胞表现通常需要在使用前向培养基中添加L-谷氨酰胺补充剂。

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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L-谷氨酰胺

L-Glutamine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1125

L-谷氨酰胺

L-Glutamine solution 200 mM, Hybri-Max™, sterile-filtered, suitable for hybridoma

Sigma-Aldrich

G2150

L -谷氨酰胺 溶液

L-Glutamine for biochemistry

Millipore

1.00289

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Rebekah M Samsonraj et al.
Stem cells (Dayton, Ohio), 33(6), 1878-1891 (2015-03-11)
This study sought to identify critical determinants of mesenchymal stem cell (MSC) potency using in vitro and in vivo attributes of cells isolated from the bone marrow of age- and sex-matched donors. Adherence to plastic was not indicative of potency
Pablo Hernández-Varas et al.
Nature communications, 6, 7524-7524 (2015-06-26)
Cell-matrix adhesions are central mediators of mechanotransduction, yet the interplay between force and adhesion regulation remains unclear. Here we use live cell imaging to map time-dependent cross-correlations between vinculin-mediated tension and adhesion complex area, revealing a plastic, context-dependent relationship. Interestingly
Lisa A Reynolds et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2984-2993 (2014-08-13)
Helminth parasites remain one of the most common causes of infections worldwide, yet little is still known about the immune signaling pathways that control their expulsion. C57BL/6 mice are chronically susceptible to infection with the gastrointestinal helminth parasite Heligmosomoides polygyrus.
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Nature communications, 5, 4287-4287 (2014-07-06)
The exosome is a multi-protein complex, required for the degradation of AU-rich element (ARE) containing messenger RNAs (mRNAs). EXOSC8 is an essential protein of the exosome core, as its depletion causes a severe growth defect in yeast. Here we show
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Genome biology, 16, 156-156 (2015-08-28)
Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed HiCap, which combines a 4-cutter restriction enzyme Hi-C with sequence capture of promoter regions. Applying the

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Importance and uses of glutamine in hybridoma and mammalian cell culture

Chromatograms

application for HPLC

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