Merck

G6129

Sigma-Aldrich

鸟苷-3′,5′-环一磷酸 钠盐

≥99% (HPLC), powder

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别名:
3′,5′-环GMP 单钠盐, 3′,5′-环磷酸鸟苷钠, cGMP, 环GMP, 鸟苷-3′,5′-环磷酸酯 单钠盐
Empirical Formula (Hill Notation):
C10H11N5NaO7P
CAS号:
分子量:
367.19
Beilstein:
6467425
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥99% (HPLC)

形式

powder

颜色

white

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES string

[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1

InChI

1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

KMPIYXNEROUNOG-GWTDSMLYSA-M

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此商品
G7504A6885C9630
Guanosine 3′,5′-cyclic monophosphate ≥98% (HPLC), powder

Sigma-Aldrich

G7504

鸟苷 3',5'-环单磷酸

form

powder

form

powder

form

powder

form

powder

color

white

color

white

color

white

color

-

solubility

H2O: 50 mg/mL

solubility

0.2 M NaHCO3: 50 mg/mL

solubility

H2O: 10 mg/mL

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

生化/生理作用

作为重要的第二信使,cGMP是细胞外信号(例如一氧化氮和利尿钠肽)的主要细胞内介质。环状GMP可与三种类型的细胞内受体蛋白相互作用:cGMP依赖性蛋白激酶、cGMP调节的通道、以及cGMP调节的环核苷酸磷酸二酯酶。cGMP水平在体内升高的主要作用是刺激cGMP依赖性蛋白激酶(PKG)。

特点和优势

《受体分类和信号转导》手册的 磷酸二酯酶以及PKA & PKG页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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C Picco et al.
The Journal of physiology, 460, 741-758 (1993-01-01)
1. The permeability of the channel activated by guanosine 3',5'-cyclic monophosphate (cGMP) to many organic monovalent cations was determined by recording macroscopic currents in excised inside-out patches of plasma membrane from isolated retinal rod outer segments of the tiger salamander.
G Colamartino et al.
The Journal of physiology, 440, 189-206 (1991-01-01)
1. Blockage and permeation of divalent cations through channels activated by guanosine 3',5'-cyclic monophosphate (cyclic GMP) were studied in membrane patches excised from retinal rods of the tiger salamander Ambystoma tigrinum by rapidly changing the ionic medium bathing the intracellular
Katja S Kroker et al.
Neurobiology of aging, 35(9), 2072-2078 (2014-04-22)
The cyclic nucleotide cGMP is an important intracellular messenger for synaptic plasticity and memory function in rodents. Therefore, inhibition of cGMP degrading phosphodiesterases, like PDE9A, has gained interest as potential target for treatment of cognition deficits in indications like Alzheimer's
You-Lin Tain et al.
Biology of reproduction, 92(1), 7-7 (2014-11-15)
Nitric oxide (NO) deficiency induced by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME) resulted in hypertension. L-citrulline (CIT) can be converted to L-arginine to generate NO. We examined whether maternal CIT supplementation can prevent L-NAME-induced programmed hypertension. Pregnant Sprague-Dawley
Sofia-Iris Bibli et al.
Cardiovascular research, 106(3), 432-442 (2015-04-15)
H2S is known to confer cardioprotection; however, the pathways mediating its effects in vivo remain incompletely understood. The purpose of the present study is to evaluate the contribution of cGMP-regulated pathways in the infarct-limiting effect of H2S in vivo. Anaesthetized

商品

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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