Merck

G8877

Sigma-Aldrich

鸟苷5′-三磷酸 钠盐 水合物

≥95% (HPLC), powder

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别名:
GTP
Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+
CAS号:
分子量:
523.18 (free acid basis)
Beilstein:
3585677
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥95% (HPLC)

形式

powder

颜色

white

溶解性

H2O: 50 mg/mL

运输

dry ice

储存温度

−20°C

SMILES string

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

KZRMTEVIDYXWQW-CYCLDIHTSA-K

Gene Information

human ... HRAS(3265)

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G6129G7504G8634
Guanosine 3′,5′-cyclic monophosphate ≥98% (HPLC), powder

Sigma-Aldrich

G7504

鸟苷 3',5'-环单磷酸

form

powder

form

powder

form

powder

form

powder

color

white

color

white

color

white

color

white to off-white

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

0.2 M NaHCO3: 50 mg/mL

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

应用

鸟苷5′-三磷酸钠盐水合物已用于:
  • 辣根过氧化物酶(HRP)修饰的平板试剂制备
  • 全细胞电压钳记录
  • 转谷氨酰胺酶(tTG)的体外抑制

生化/生理作用

GTP可用作参与到将化学能导入至特定的生物合成途径的磷酸酶和焦磷酸酶载体。GTP可将参与到包括增殖、分化等多种细胞过程的信号转导G蛋白进行激活,以及多种细胞间激酶级联反应的激活。增殖和凋亡是部分受到由小GTPase Ras和Rho介导的GTP水解调控的。另一种类型的小GTPase,Rab可在囊泡的对接和融合中起到作用,并也可能参与到囊泡的形成。除了在信号转导中发挥作用外,GTP还可在DNA和RNA的酶促生物合成中作为单核苷酸单位的富含能量前体。

特点和优势

该化合物是环状核苷酸研究的特色产品。点击此处以发现更多的环状核苷酸特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。

制备说明

由5′-GMP的酶促磷酸化而制备。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Feng Rao et al.
Analytical biochemistry, 389(2), 138-142 (2009-03-31)
The cyclic dinucleotide c-di-GMP is a widespread bacterial messenger molecule with potential application as a therapeutic agent for treating bacterial infection. Current enzymatic synthesis of c-di-GMP using mesophilic diguanylate cyclase (DGC) proteins suffers from low production yield due to protein
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase
Molberg O, et al.
European Journal of Immunology, 31(5), 1317-1323 (2001)
Benjamin Judkewitz et al.
Nature protocols, 4(6), 862-869 (2009-05-16)
In order to link our knowledge of single neurons with theories of network function, it has been a long-standing goal to manipulate the activity and gene expression of identified subsets of mammalian neurons within the intact brain in vivo. This
Rob P M van Gijlswijk et al.
Clinical chemistry, 48(8), 1352-1359 (2002-07-27)
Microarray platforms will change immunochemical and nucleic acid-based analysis of cell homogenates and body fluids compared with classic analyses. Microarrays use labeled target and immobilized probes, rather than fixed targets and labeled probes. We describe a method for simultaneous labeling
Flufenamic acid affects multiple currents and causes intracellular Ca2+ release in Aplysia bag cell neurons
Gardam K E, et al.
Journal of Neurophysiology, 100(1), 38-49 (2008)

实验方案

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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