Merck
所有图片(4)

H0888

Sigma-Aldrich

氢化可的松

BioReagent, suitable for cell culture

别名:
皮质醇, 11β,17α,21-三羟基孕甾-4-烯-3,20-二酮, 17-羟基皮质甾酮, 氢化泼尼松龙, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 氢化皮质酮
Empirical Formula (Hill Notation):
C21H30O5
CAS号:
分子量:
362.46
Beilstein:
1354819
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

生物来源

plant (wild yam)

产品线

BioReagent

测定

≥98%

形式

powder

technique(s)

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

溶解性

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

运输

ambient

储存温度

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

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相关类别

应用

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

包装

1, 5, 10 g in poly bottle

生化/生理作用

肾上腺皮质分泌的原发性糖皮质激素。消炎效果是皮质酮的三倍,但 Na2+ 保留性能比皮质酮低。
Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.

外形

室温下为粉末状;分成小份冻存,以避免使用时反复冷冻/解冻

重悬

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Repr. 1A - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

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Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses.
Briegel J et al.
Journal of the American Society of Nephrology, 12, S70-S70 (2001)
Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.
Dame MK et al.
In Vitro Cellular & Developmental Biology. Animal, 46, 114-114 (2010)
The cortisol awakening response (CAR): facts and future directions.
Fries E et al.
International Journal of Psychophysiology, 72, 67-67 (2009)
A J Kent et al.
Biomaterials, 218, 119337-119337 (2019-07-22)
Laminin-111 (Ln-1), an extracellular matrix (ECM) glycoprotein found in the basement membrane of mammary gland epithelia, is essential for lactation. In mammary epithelial cells (MECs), dystroglycan (Dg) is believed to be necessary for polymerization of laminin-111 into networks., thus we
Marc Hafner et al.
Cell chemical biology, 26(8), 1067-1080 (2019-06-11)
The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, it is often unclear whether therapeutics with the same nominal targets but different chemical structures are

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