H0888

氢化可的松

BioReagent, suitable for cell culture

• 别名: 皮质醇, 11β,17α,21-三羟基孕甾-4-烯-3,20-二酮, 17-羟基皮质甾酮, 氢化泼尼松龙, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 氢化皮质酮
• Empirical Formula (Hill Notation): C₂₁H₃₀O₅
• CAS号: 50-23-7
• 分子量: 362.46
• Beilstein: 1354819
• EC 号: 200-020-1
• MDL编号: MFCD00011654
• PubChem化学物质编号: 24895415
• NACRES: NA.77

属性

• 质量水平: 200
• 生物来源: plant (wild yam)
• 产品线: BioReagent
• 测定: ≥98%
• 形式: powder
• technique(s): cell culture | mammalian: suitable
• mp: 211-214 °C (lit.)
• 溶解性: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
• 运输: ambient
• 储存温度: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) ; rat ... Ar(24208) , Nr3c1(24413)

说明

应用

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

包装

1, 5, 10 g in poly bottle

生化/生理作用

肾上腺皮质分泌的原发性糖皮质激素。消炎效果是皮质酮的三倍，但 Na²⁺ 保留性能比皮质酮低。

Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.

外形

室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻

重悬

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H360Df - H373
• 预防措施声明: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危险分类: Repr. 1A - STOT RE 2
• 储存分类代码: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges