Merck
所有图片(4)

H3160

Sigma-Aldrich

氢化可的松

meets USP testing specifications

别名:
皮质醇, 11β,17α,21-三羟基孕甾-4-烯-3,20-二酮, 17-羟基皮质甾酮, 氢化泼尼松龙, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 氢化皮质酮
Empirical Formula (Hill Notation):
C21H30O5
CAS号:
分子量:
362.46
Beilstein:
1354819
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.21

质量水平

300

生物来源

plant (wild yam)

Agency

USP/NF
meets USP testing specifications

测定

97.0-102.0% dry basis

形式

powder

效能

0.004-0.005 μg/mL

mp

211-214 °C (lit.)

溶解性

water: soluble 0.28 g/L at 25 °C

application(s)

pharmaceutical (small molecule)

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

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包装

5, 10, 25 g in poly bottle

生化/生理作用

肾上腺皮质分泌的原发性糖皮质激素。消炎效果是皮质酮的三倍,但 Na2+ 保留性能比皮质酮低。

外形

室温下为粉末状;分成小份冻存,以避免使用时反复冷冻/解冻

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Repr. 1A - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants.
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The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
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The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD

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