H4014

Sigma-Aldrich

25-羟基胆钙化醇

≥98% (HPLC)

别名:
25-羟基维生素D3
Empirical Formula (Hill Notation):
C27H44O2
CAS号:
分子量:
400.64
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.79

质量水平

200

测定

≥98% (HPLC)

形式

powder

应用

HPLC: suitable

颜色

white to off-white

储存温度

−20°C

SMILES string

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

InChI key

JWUBBDSIWDLEOM-DTOXIADCSA-N

Gene Information

human ... VDR(7421)

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相关类别

包装

1 mg in glass bottle

生化/生理作用

麦角钙化醇(维生素D2)和25-羟基胆钙化醇(维生素D3)是维生素D的两种形式,它们可通过羟基化在 体内 活化。 维生素D2和D3可用于广泛的研究,以评估其对免疫功能和钙稳态等功能的影响。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

个人防护装备

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RIDADR

UN 2811 6.1 / PGII

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Richard McKenzie et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 12(9), 1726-1737 (2013-06-29)
To clarify the relation between UV exposure and vitamin D status, 201 volunteers wore personal electronic UV dosimeters during daylight hours, to record their UV exposure over a 10 week period when ambient UV levels were significantly less than the...
Julia Höbaus et al.
International journal of cancer, 133(6), 1380-1388 (2013-03-07)
In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). However, the underlying mechanism of CYP24A1 overexpression is poorly understood. In...
Bianca Weinstock-Guttman et al.
Journal of neurology, neurosurgery, and psychiatry, 84(11), 1186-1191 (2013-04-19)
To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment...
Maria Samefors et al.
European journal of endocrinology, 170(5), 667-675 (2014-02-13)
Institutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency. In addition to osteoporosis-related disorders, vitamin D deficiency may influence several medical conditions conferring an increased mortality risk. The aim of this study was to...
M Abboud et al.
Endocrinology, 154(9), 3022-3030 (2013-07-05)
Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In...

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