H5752

17α-羟基孕酮

≥95%

• 别名: 17α-羟基孕甾-4-烯-3,20-二酮, 17α-羟基黄体酮
• 经验公式（希尔记法）: C₂₁H₃₀O₃
• CAS号: 68-96-2
• 分子量: 330.46
• Beilstein: 3218109
• EC號碼: 200-699-4
• MDL號碼: MFCD00003659
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278469
• NACRES: NA.77

属性

• 生物源: synthetic (organic)
• 品質等級: 200
• 無菌: non-sterile
• 化驗: ≥95%
• 形狀: powder
• 溶解度: chloroform: 50 mg/mL, clear, colorless to light yellow
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O
• InChI: 1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
• InChI 密鑰: DBPWSSGDRRHUNT-CEGNMAFCSA-N
• 基因資訊: human ... PGR(5241) , SERPINA6(866) ; rat ... Ar(24208)

说明

一般說明

17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.

應用

17α-Hydroxyprogesterone has been used:

• for titration against ovarian S9 protein in thin-layer chromatography
• as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
• as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)

生化／生理作用

17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).

安全信息

• 象形圖: GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H360FD,H411
• 防範說明: P202 - P273 - P280 - P308 + P313 - P391 - P405
• 危險分類: Aquatic Chronic 2 - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges