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H6536

单克隆抗- HIF-1α 小鼠抗

~1 mg/mL, clone H1α67, purified immunoglobulin, buffered aqueous solution

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别名:

抗缺氧诱导因子 1α 亚单位

MDL编号:

MFCD01633488

NACRES:

NA.41

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此商品	SAB5200017	SAB1306172	SAB1405933
Sigma-Aldrich H6536 单克隆抗- HIF-1α 小鼠抗	Sigma-Aldrich SAB5200017 抗 HIF-1α 单克隆抗体小鼠抗	Sigma-Aldrich SAB1306172 ANTI-HIF1ALPHA(C-TERMINAL) antibody produced in rabbit	Sigma-Aldrich SAB1405933 Anti-HIF1A antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone H1α67, monoclonal	clone ESEE122, monoclonal	clone polyclonal	clone polyclonal
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous solution	form buffered aqueous solution
mol wt antigen 120 kDa	mol wt -	mol wt 92670 Da	mol wt antigen ~82.7 kDa

一般描述

缺氧诱导因子-1 (HIF-1) 是一种 120kD 的碱性螺旋-环-螺旋蛋白，属于转录因子 PAS 超家族。在激活缺氧诱导基因的转录中具有至关重要的作用。还可以激活 NIP3 的编码基因表达；随后在持续性缺氧下诱导细胞凋亡。单克隆抗 HIF-1α 抗体可用于免疫染色检测 HIF-1α 定位。它也可以用于蛋白质印迹。小鼠抗 HIF-1α 抗体与羊、小鼠、大鼠、雪貂和人的 HIF1α 亚基发生特异性反应。

缺氧诱导因子-1(HIF-1)是一种120kD的碱性螺旋环螺旋蛋白，属于PAS转录因子超家族。在激活缺氧诱导基因转录上起关键作用。还可激活NIP3编码基因表达，Nip3蛋白在长期缺氧条件下会诱导细胞凋亡。HIF-1α单克隆抗体可用于免疫染色法HIF-1α定位。它还可用于蛋白印迹分析。小鼠抗HIF-1α抗体与绵羊、小鼠、大鼠、雪貂和人的HIF1α亚基特异性反应。

免疫原

人 HIF-1α 蛋白 432-528 位氨基酸对应的肽。

应用

单克隆抗 HIF-1α 抗体（1：500 稀释）可用于免疫荧光共聚焦显微镜检查。也可用于免疫印迹、免疫沉淀和免疫组化。

成功使用该抗体的应用以及相关同行评审论文如下所示。
免疫组化（1 篇）

外形

溶于含 0.25 M 氯化钠和 0.1% 叠氮化钠的 0.02 M 磷酸盐缓冲液中。

免责声明

除非我们的目录或产品随附的其他公司文档中另有说明，我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人或动物的任何类型的消费或应用。

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(F)

Not applicable

闪点(C)

Not applicable

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Sigma-Aldrich

SAB5200304

Monoclonal Anti-Mmp9 - Apc antibody produced in mouse

Sigma-Aldrich

SAB2108674

Anti-HIF1A

Sigma-Aldrich

SAB5600056

Anti-HIF-1 alpha antibody, Rabbit monoclonal

Sigma-Aldrich

SAB1403916

Monoclonal Anti-HIF1A, (C-terminal) antibody produced in mouse

Knockdown of dickkopf2 inhibits vascular endothelia growth factor expression through the Wnt/β-catenin signaling pathway in human retinal pigment epithelial cells under hypoxic conditions.

Yu Zhao et al.

Experimental and therapeutic medicine, 15(4), 4056-4060 (2018-03-28)

Hypoxia has been demonstrated to be a proangiogenic factor that induces vascular endothelial growth factor (VEGF) in retinal pigment epithelial (RPE) cells. Dickkopf2 (DKK2), originally known as Wnt antagonist, has recently been demonstrated to have an important regulatory role in

DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia.

Lei Xiong et al.

The FEBS journal, 279(23), 4318-4326 (2012-10-09)

Several studies have identified a set of hypoxia-regulated microRNAs, among which is miR-210, whose expression is highly induced by hypoxia in various cancer cell lines. Recent studies have highlighted the importance of miR-210 and its transcriptional regulation by the transcription

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells.

Snider Desir et al.

Oncotarget, 7(28), 43150-43161 (2016-05-26)

In this study, we demonstrated that hypoxic conditions stimulated an increase in tunneling nanotube (TNT) formation in chemoresistant ovarian cancer cells (SKOV3, C200).We found that suppressing the mTOR pathway using either everolimus or metformin led to suppression of TNT formation

Regulation of 11β-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-κB and HIF-1α.

Jong Han Lee et al.

American journal of physiology. Endocrinology and metabolism, 304(10), E1035-E1041 (2013-03-21)

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is involved in the pathogenesis of type 2 diabetes by generating active glucocorticoids (cortisol and corticosterone) that are strong inhibitors of angiogenesis. However, the mechanism of 11β-HSD1 gene expression and its relationship to adipose angiogenesis

Neoangiogenesis contributes to the development of hemophilic synovitis.

Suchitra S Acharya et al.

Blood, 117(8), 2484-2493 (2010-12-18)

Joint arthropathy secondary to recurrent hemarthroses remains a debilitating complication of hemophilia despite the use of prophylactic factor concentrates. Increased vascularity and neoangiogenesis have been implicated in the progression of musculoskeletal disorders and tumor growth. We hypothesized that de novo

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单克隆抗- HIF-1α 小鼠抗

~1 mg/mL, clone H1α67, purified immunoglobulin, buffered aqueous solution

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免疫原

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储存分类代码

WGK

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