所有图片(3)

H7904

Sigma-Aldrich

(Z)-4-羟三苯氧胺

≥98% Z isomer

别名:
(Z)-4-(1-[4-(二甲氨基乙氧基)苯基]-2-苯基-1-丁烯基)苯酚, 反式-4-羟三苯氧胺, (Z)-4-OHT
Empirical Formula (Hill Notation):
C26H29NO2
CAS号:
分子量:
387.51
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

300

测定

≥98% (HPLC)

形式

powder

储存条件

desiccated
protect from light

溶解性

methanol: 10 mg/mL
ethanol: 20 mg/mL (with heating)

作用机制

enzyme | inhibits

抗生素抗菌谱

neoplastics

创始人

AstraZeneca

储存温度

2-8°C

SMILES string

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3

InChI

1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

TXUZVZSFRXZGTL-QPLCGJKRSA-N

包装

5, 25 mg in glass bottle

生化/生理作用

4-羟基他莫昔芬是他莫昔芬(tamoxifen)的活性代谢物,结合雌激素受体(ER)和雌激素相关受体(ERR),具有雌激素和抗雌激素作用。它是细胞渗透性的选择性雌激素受体调节剂(SERM)。在配体依赖内含肽工程Cas9变体中,4-羟基他莫昔芬用于调控Cas9功能,降低CRISPR介导的基因编辑的脱靶效应。

特点和优势

该化合物由AstraZeneca开发。如需浏览其他药物开发的化合物和批准的药物/候选药物清单,请单击此处
该化合物是受体分类及信号转导手册上核受体(类固醇)页面上的特色化合物。如需浏览其他手册页面,请点击此处

其他说明

Scripps Center for Metabolomics(斯克里普斯代谢组学中心)独立生成的串联质谱数据,可以PDF格式查看或下载。H7904.pdf 经过测试的代谢物在Scripps Center for Metabolomics(斯克里普斯代谢组学中心) METLIN 代谢物数据库中有重点介绍。更多信息请见sigma.com/metlin。

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

原产地证书 (CofO)

Pei-Shan Hou et al.
Nature communications, 10(1), 3581-3581 (2019-08-10)
The bimodal requisite for a genetic program and external stimuli is a key feature of sensory circuit formation. However, the contribution of cell-intrinsic codes to directing sensory-specific circuits remains unknown. Here, we identify the earliest molecular program that preselects projection
Natalia L Kononenko et al.
Nature communications, 8, 14819-14819 (2017-04-08)
Autophagosomes primarily mediate turnover of cytoplasmic proteins or organelles to provide nutrients and eliminate damaged proteins. In neurons, autophagosomes form in distal axons and are trafficked retrogradely to fuse with lysosomes in the soma. Although defective neuronal autophagy is associated
Emily R Moore et al.
Stem cell research & therapy, 9(1), 190-190 (2018-07-13)
The fully developed adult skeleton adapts to mechanical forces by generating more bone, usually at the periosteal surface. Progenitor cells in the periosteum are believed to differentiate into bone-forming osteoblasts that contribute to load-induced adult bone formation, but in vivo evidence
Kevin M Davis et al.
Nature chemical biology, 11(5), 316-318 (2015-04-08)
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that are activated by the presence of a cell-permeable small molecule by inserting an evolved
Marcus Conrad et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(36), 15774-15779 (2010-08-28)
Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive oxygen species (ROS), like H(2)O(2), as the mediators of PTP oxidation. The potential role(s) of peroxidized lipids in PTP oxidation have

技术文章

Small Molecule CRISPR Enhancers

The CRISPR-Cas9 system is an RNA-guided genome-editing tool that provides researchers a simple, easy, and quick way to modify the genomes of various organisms.

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