HMI0026

Sigma-Aldrich

MISSION® microRNA Mimic

hsa-miR-101

别名:
hsa-miR-101-3p
NACRES:
NA.51

Quality Level

product line

MISSION®

mature sequence

UACAGUACUGUGAUAACUGAA

Sanger mature/minor accession no.

Sanger microRNA accession no.

storage temp.

−20°C

Gene Information

General description

The ready-to-use MISSION miRNA mimics are small, double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules when introduced into cells. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation. MISSION miRNA Mimics, a member of MISSION RNAi product family, provides miRNA researchers with a range of options from individual MISSION mimics to a full library of human miRNA mimics based on latest version of miRBase (currently hosted by the University of Manchester, previously hosted by the Sanger Institute).

  • Optimized and ready for transfection.
  • Novel MISSION miRNA mimic design has been functionally tested for knockdown efficiency against natural miRNA targets.
  • Unique MISSION miRNA mimic design significantly reduces possible sense strand off target effects.
  • Available as a whole human library and individual miRNA targets.

Biochem/physiol Actions

The miRNA hsa-miR-101-3p is responsible for the regulation of TGFBR1 (TGF-β receptor type-1), TGFBR2, ACVR2B (activin receptor type-2B) and BMPR2 (bone morphogenetic protein receptor type-2) and TGF-β (transforming growth factor). It is differentially expressed in humans with latent tuberculosis versus active tuberculosis. It is downregulated in various cancers, such as esophageal squamous cell carcinoma, prostate and colorectal cancer. The hsa-miR-101-3p inhibits cancer cell proliferation, migration and invasion by targeting genes including cyclooxygenase-2 (COX-2), EZH2 (histone-lysine N-methyltransferase), Mcl-1 (induced myeloid leukemia cell differentiation protein), mTOR (mechanistic target of rapamycin).

Other Notes

miRBase V18 Mature ID update: hsa-miR-101-3p

Legal Information

MISSION is a registered trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Deregulated microRNAs in CD4+ T cells from individuals with latent tuberculosis versus active tuberculosis.
Fu Y
Journal of Cellular and Molecular Medicine, 18, 503-503 (2014)
De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development.
Sanchez-Diaz PC
PLoS ONE, 8, e61622-e61622 (2013)
Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway.
Gong J
Oncology Reports, 35, 463-463 (2016)

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