Merck

HPA010775

Sigma-Aldrich

抗-NECTIN4 兔抗

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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别名:
LNIR 兔抗, PRR4, PVRL4
人类蛋白质图谱编号:

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

形式

buffered aqueous glycerol solution

species reactivity

human

包装

antibody small pack of 25 μL

增强验证

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

免疫原序列

KLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPAL

运输

wet ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... PVRL4(81607)

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此商品
SAB1408046SAB4200370HPA012759
Anti-NECTIN4 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA010775

抗-NECTIN4 兔抗

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

N4.101.10, monoclonal

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

-

product line

-

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

一般描述

PVRL4(脊髓灰质炎病毒受体相关4)属于一个叫做nectins的细胞粘附分子家族,而nectins又属于免疫球蛋白超家族。它具有胞质尾结构域,单个跨膜结构域和胞外区的三个免疫球蛋白样结构域。由于可变剪接,PVRL4具有两种亚型,其中一种缺乏氨基酸412-436。在人类中,该基因位于染色体1q23。与nectin家族的其他成员不同,PVRL4(也称为nectin-4)主要在胚胎和胎盘中表达。

免疫原

nectin细胞黏附分子4重组蛋白表位标签 (PrEST)

应用

兔产生的抗PVRL4抗体,属于Prestige抗体,由人类蛋白质图谱(HPA)项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接,可以在人类蛋白质图谱(HPA)站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息,请访问 sigma.com/prestige

生化/生理作用

PVRL4(脊髓灰质炎病毒受体相关4)与nectin-1形成同二聚体或异二聚体,以促进细胞粘附。它还促使麻疹病毒在人气道内衬的原发性上皮细胞中的进入和侧向传播。它在多种癌症中高度表达,例如乳腺癌,肺癌和卵巢癌。它对麻疹病毒和在癌症细胞中表达的特异性使其成为一种潜在的溶瘤工具。 PVRL4基因突变与外胚层发育不良-并指综合征(EDSS)相关,该综合征的特征是头发和牙齿异常,脱发和皮肤并指。在EDSS患者的角质形成细胞中,突变的PVRL4无法与nectin-1形成二聚体。它在非小细胞肺癌(NSCLC)中高表达,并与不良预后相关。因此,它可能参与肺癌的肿瘤发生,并具有作为标志物和NSCLC治疗靶标的潜力。

特点和优势

Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。

每种Prestige 抗体的检测方法如下:
  • 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
  • 364个人重组蛋白片段的蛋白阵列。

联系

相应抗原APREST72029

外形

磷酸盐缓冲盐水溶液,pH 7.2,含有40%甘油和0.02%叠氮化钠

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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