HPA029432

Anti-CLEC4C antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-BDCA2, Anti-C-type lectin domain family 4, member C, Anti-CD303, Anti-CLECSF11, Anti-CLECSF7, Anti-DLEC, Anti-HECL
• 人类蛋白质图谱编号: HPA029432

Properties

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• antibody product type: primary antibodies
• 克隆: polyclonal
• 产品线: Prestige Antibodies^® Powered by Atlas Antibodies
• 形式: buffered aqueous glycerol solution
• species reactivity: human
• 增强验证: recombinant expression; Learn more about Antibody Enhanced Validation
• technique(s): immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:20-1:50
• 免疫原序列: MYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWN
• UniProt登记号: Q8WTT0
• 运输: wet ice
• 储存温度: −20°C
• Gene Information: human ... CLEC4C(170482)

Description

一般描述

The type II C-type lectin (CLEC4C), a transmembrane protein, is expressed on plasmacytoid dendritic cells (PDCs). CLEC4C is also known as CD303 or BDCA2 (blood dendritic cell antigen 2). This gene has seven exons and is mapped to human chromosome 12p13.31. CLEC4C codes for a member that belongs the C-type lectin (CLEC) domain family with 213 residues. The CLR, blood dendritic cell antigen 2 (BDCA2, CD303 or CLEC4C), is expressed principally on PDCs in humans.

免疫原

C-type lectin domain family 4, member C recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.
Anti-CLEC4C antibody produced in rabbit has been used in immunostaining.

生化/生理作用

The type II C-type lectin (CLEC4C) plays a major role in motor neuronal vulnerability. It also participates in Ag capture, internalization and presentation to T cells.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST72394.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(F): Not applicable
• 闪点(C): Not applicable