Merck

I0634

Sigma-Aldrich

离子霉素 钙盐 来源于密团链霉菌

powder, ≥98% (HPLC)

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别名:
SQ23377 calcium
Empirical Formula (Hill Notation):
C41H70CaO9
CAS号:
分子量:
747.07
Beilstein:
1416163
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated
protect from light

颜色

white to off-white

溶解性

DMSO: 10 mg/mL
ethanol: soluble

抗生素抗菌谱

Gram-positive bacteria

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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沙卡布曲 钙盐

form

powder

form

waxy solid

form

powder

form

powder

storage condition

desiccated, protect from light

storage condition

OK to freeze, protect from light

storage condition

desiccated

storage condition

desiccated

color

white to off-white

color

-

color

white to beige

color

white to beige

solubility

DMSO: 10 mg/mL, ethanol: soluble

solubility

DMSO: 10 mg/mL, methanol: 10 mg/mL

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

应用

来自Streptomyces conglobatus的离子霉素钙盐已用作介质补充剂,以培养
  • 用于免疫评估的外周血单核细胞(PBMC)
  • 用于孤雌激活的卵母细胞
  • T细胞亚群用于胞内细胞因子检测、羧基荧光素二乙酸琥珀酰亚胺酯(CFSE)增殖试验和抗原特异性抑制功能测定

生化/生理作用

比A23187更有效地作为Ca2+ 的移动离子载体的Ca2+ 离子载体;无荧光;用于研究Ca2+ 跨生物膜的运输;诱导胚胎皮层神经元凋亡变性。
离子霉素是一种离子载体,广泛应用于钙分析的验证和校准。

制备说明

在 2-8 °C 下以干燥和避光的粉末形式储存伊屋诺霉素。 在这些条件下,产品可在3年内保持稳定。在 -20 °C 下将储备溶液在乙醇或 DMSO 中避光保存。在这些条件下储备溶液可在数月内保持稳定。对于短期用途(最多6星期),可将储备溶液在2-8 °C下避光保存。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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