Merck
All Photos(2)

I7018

Sigma-Aldrich

3-异丁基-1-甲基黄嘌呤

BioUltra, ≥99%

Synonym(s):
1-甲基-3-异丁基黄嘌呤, 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮, 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮, IBMX
Empirical Formula (Hill Notation):
C10H14N4O2
CAS Number:
Molecular Weight:
222.24
Beilstein:
247859
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

产品线

BioUltra

质量水平

200

测定

≥99%

杂质

<0.005% Phosphorus (P)

灼烧残渣

<0.1%

mp

200-201 °C (lit.)

溶解性

DMSO: soluble 1 M (with gentle warming)

痕量阴离子

sulfate (SO42-): <0.05%

痕量阳离子

Al: <0.0005%
Ca: <0.005%
Cu: <0.0005%
Fe: <0.005%
K: <0.05%
Mg: <0.005%
NH4+: <0.05%
Na: <0.005%
Pb: <0.001%
Zn: <0.0005%

储存温度

−20°C

SMILES string

CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12

InChI

1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

InChI key

APIXJSLKIYYUKG-UHFFFAOYSA-N

Gene Information

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Related Categories

应用

3-异丁基-1-甲基黄嘌呤是一种腺苷3′,5′-环但但磷酸磷酸二酯酶 (cAMP PDE)抑制剂,已用于:
  • 成脂分化[1]
  • 组织培养[2]
  • 3T3-L1脂肪前体细胞分化[3]

包装

1 g in poly bottle

生化/生理作用

由IBMX对磷酸二酯酶的抑制而引起的cAMP水平的增加可激活PKA,而引起增殖减少、分化增加并诱导细胞凋亡。IBMX可抑制苯肾上腺素诱导的气道粘膜神经内分泌上皮细胞5-羟色胺释放。(IC50:1.3 μM)。IBMX还可作为一种腺苷受体拮抗剂。其已表现出对神经肌肉接头、GH3细胞和血管平滑肌细胞中离子通道的抑制作用。IBMX可诱导感觉神经元释放储存在细胞内的钙。

特点和优势

  • ICP法痕量元素检测
  • ICP检测痕量硫(硫酸盐形式)和磷(磷酸盐形式)含量
  • 离子色谱法检测痕量铵含量

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificate of Analysis

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Certificate of Origin

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