K1128

α-酮戊二酸

BioReagent, suitable for cell culture, suitable for insect cell culture

• Synonym(s): 2-氧代戊二酸, 2-氧化戊二酸
• Linear Formula: HOOCCH₂CH₂COCOOH
• CAS Number: 328-50-7
• Molecular Weight: 146.10
• Beilstein: 1705689
• EC 号: 206-330-3
• MDL编号: MFCD00004165
• PubChem化学物质编号: 24896202
• NACRES: NA.32

Properties

• 产品线: BioReagent
• 质量水平: 200
• 测定: ≥98.5% NaOH basis (titration)
• 形式: powder or crystals
• technique(s): cell culture | insect: suitable; cell culture | mammalian: suitable
• 溶解性: water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
• 储存温度: 2-8°C
• SMILES string: OC(=O)CCC(=O)C(O)=O
• InChI: 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
• InChI key: KPGXRSRHYNQIFN-UHFFFAOYSA-N

Description

一般描述

Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.

应用

α-Ketoglutaric acid has been used:

• as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis
• for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms
• as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)

包装

1, 5, 25, 100, 500 g

生化/生理作用

Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine. It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle. It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism. In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects. This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.

Safety Information

• 象形图: GHS05
• 警示用语：: Danger
• 危险声明: H318
• 预防措施声明: P280 - P305 + P351 + P338 + P310
• 危险分类: Eye Dam. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Gloves