Merck

L3129

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0127:B8

purified by phenol extraction

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别名:
LPS
EC 号:
MDL编号:
NACRES:
NA.25

生物来源

Escherichia coli (O127:B8)

质量水平

形式

lyophilized powder

纯化方式

phenol extraction

杂质

<3% Protein (Lowry)

颜色

white to faint yellow

溶解性

water: soluble

运输

ambient

储存温度

2-8°C

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此商品
L5024L5668L4516
vibrant-m

L3129

脂多糖 来源于大肠杆菌 0127:B8

-
vibrant-m

L5024

脂多糖 来源于大肠杆菌 0127:B8

-
vibrant-m

L5668

脂多糖 来源于大肠杆菌 0127:B8

-
vibrant-m

L4516

脂多糖 来源于大肠杆菌 0127:B8

Premium Grade
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: soluble

solubility

water: soluble

solubility

water: soluble

solubility

H2O: 5 mg/mL, slightly hazy

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous solution

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

impurities

<3% Protein (Lowry)

impurities

<1% Protein, <1% RNA

impurities

-

impurities

<1% Protein (Lowry)

一般描述

该产物是从大肠杆菌血清型O127:B8中苯酚提取得到。源菌株为ATCC 12740。该LPS血清型已经用于脓毒性休克的研究,并且可在大鼠肾小球masangial细胞中诱导小鼠巨噬细胞和PAF中的NOS合成。

应用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式(PAMP)的Toll样受体蛋白家族成员Toll样受体4(TLR4)刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性,并保护细胞免受胆汁盐和亲脂性抗生素的作用。

制备说明

该产品可溶于水(5mg/mL)或细胞培养基(1mg/mL),并产生浑浊的淡黄色溶液。在涡旋并升温至70-80 oC后,在盐水中可获得更加浓缩但仍然浑浊的溶液(20mg/ml)。脂多糖是一种能在各种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。通过有机溶剂无法获得更澄清的溶液。在甲醇会产生含有漂浮物的混浊悬浮液,而在水中则产生均匀的浑浊溶液。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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In humans, depression is often associated with low-grade inflammation, activation of the tryptophan/kynurenine pathway, and mild lymphopenia. Preclinical research confirms that inflammation induces depression-like behavior through activation of the tryptophan/kynurenine pathway. However, the mechanisms governing recovery from depression are unknown.
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