L3669

Sigma-Aldrich

LPK-26

≥98% (HPLC), powder

别名:
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(2-isopropyl)-2-(1-(3-pyrrolinyl))ethyl]acetamide hydrochloride
Empirical Formula (Hill Notation):
C18H24Cl2N2O · HCl
CAS号:
分子量:
391.76
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CC(C)[C@@H](CN1CC=CC1)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2

InChI

1S/C18H24Cl2N2O.ClH/c1-13(2)17(12-22-8-4-5-9-22)21(3)18(23)11-14-6-7-15(19)16(20)10-14;/h4-7,10,13,17H,8-9,11-12H2,1-3H3;1H/t17-;/m1./s1

Inchi Key

WOOCHAFXTYNYQE-UNTBIKODSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). It has extremely high kappa affinity (0.64 nM) and low mu and delta receptor affnities (1170 and 10,000nM). LPK-26 produces an antinocicpetive effect with much higher potency in vivo than morphine or U50488. LPK-26 does not produce physical dependence in mice, but it does suppress naloxone-induced behavioral effects in mice treated with morphine.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

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