Merck

L4146

Sigma-Aldrich

瘦素 人

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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别名:
OB
MDL编号:
NACRES:
NA.32

重组

expressed in E. coli

质量水平

无菌性

sterile; 0.2 μm filtered

检测方案

≥97% (SDS-PAGE)

形式

lyophilized powder

效能

≤3.0 ng/mL ED50/EC50

分子量

predicted mol wt ~16 kDa

杂质

≤1.0 EU/μg endotoxin

UniProt登记号

运输

ambient

储存温度

−20°C

基因信息

human ... LEP(3952)

相关类别

一般描述

The gene LEP (leptin) is mapped to human chromosome 7q31. It is a 16kDa peptide. Leptin is released in the circulation and goes to the CNS (central nervous system). In CNS, it works by associating with leptin receptor.

应用

Leptin human has been used:
  • to study the effect of leptin on ACAT1 (acyl-coenzyme A:cholesterol acyltransferase 1) expression and cholesterol efflux from primary cultured human macrophages
  • to study the effect of leptin on expression of IGFBP2 (insulin growth factor binding protein 2) in skeletal muscle
  • to study the effect of leptin on HLA-G (human leukocyte antigen G) expression in placental trophoblasts
  • to study the effect of leptin on in vitro maturation, fertilization and development of horse oocytes after ICSI (intracytoplasmic sperm injection)

生化/生理作用

Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Leptin is believed to play a role in normal pregnancy development.
Mutations in LEP (leptin) are linked with type-2 diabetes. Presence of high levels of leptin in plasma is related to adiposity.

外形

Lyophilized from a 0.2 μm filtered solution with 0.0045 mM NaHCO3

分析说明

The biological activity is measured by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BAF3 cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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