Merck

L9017

Sigma-Aldrich

来自 菜豆的凝集素 (红芸豆)

Phytohemagglutinin PHA-P, BioXtra, purified by affinity chromatography, lyophilized powder

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别名:
PHA, 植物血球凝集素(菜豆)
EC 号:
NACRES:
NA.32

生物来源

Phaseolus vulgaris

质量水平

产品线

BioXtra

形式

lyophilized powder

效能

≤17 μg per mL agglutination activity

纯化方式

affinity chromatography

杂质

salt, essentially free

储存温度

2-8°C

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此商品
L2769L4144L1668
form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder (contains ~50% buffer salts as sodium phosphate and NaCl)

purified by

affinity chromatography

purified by

-

purified by

-

purified by

-

impurities

salt, essentially free

impurities

salt, free

impurities

salt, free

impurities

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

product line

BioXtra

product line

-

product line

BioReagent

product line

BioReagent

一般描述

凝集素是碳水化合物结合蛋白, 含四个亚基,分子量为125kDa。白细胞凝集素PHA-L是植物凝集素,由中枢神经系统神经元转运。

应用

从菜豆( Phaseolus vulgaris )(红芸豆)中提取的凝集素,可用于:
  • 植物血凝素(PHA)膨胀测定
  • 淋巴细胞激活测定
  • 评估细胞介导的免疫反应

生化/生理作用

凝集素凝集细胞,沉淀多糖和糖蛋白。具有抗癌、抗人免疫缺陷病毒(抗-HIV)和抗微生物感染特性。凝集素与毒性过敏原和血凝素有关。凝集素可抑制粘膜萎缩、降低2型糖尿病和肥胖症、增强营养吸收和调节药物靶向。
PHA由两种分子种类组成,即具有低促有丝分裂活性和高红细胞凝集素活性的红细胞凝集素(PHA-E),和具有高促有丝分裂和白细胞凝集活性但具有非常低的红细胞凝集活性的白细胞凝集素(PHA-L)。
PHA-E不具有血型特异性,但其凝集活性可被某些低聚糖抑制。 在分离和纯化红细胞凝集素和白细胞凝集素之前,PHA-P是PHA的蛋白质形式。 PHA-M是粘蛋白形式。 结合物由相应的纯化凝集素进行制备。

质量

≤10 μg/mL时的促有丝分裂活性。

分析说明

凝集活性以 mg/mL 表示,通过 1 mg/mL 溶液的系列稀释液测定。该活性是在 25℃ 下孵育 1h 后凝集 2% 人红细胞的磷酸盐缓冲盐水 (pH 6.8) 混悬液的最低浓度。促有丝分裂活性由 BrdU 掺入决定。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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