Merck
All Photos(4)

M1404

Sigma-Aldrich

诺考达唑

≥99% (TLC), powder

Synonym(s):
R 17934, 甲基-(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸, 甲基N(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸, 诺考达唑
Empirical Formula (Hill Notation):
C14H11N3O3S
CAS Number:
Molecular Weight:
301.32
Beilstein:
1085978
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

300

测定

≥99% (TLC)

形式

powder

mp

300 °C (dec.)

溶解性

DMSO: soluble 10 mg/mL (may require heating)
H2O: insoluble

储存温度

2-8°C

SMILES string

COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

Gene Information

human ... TUBB(203068)

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包装

2, 10, 50 mg in glass bottle

应用

诺科达唑显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子,请访问 sigma.com/CRISPR-enhancers

生化/生理作用

诺考达唑(Nocodazole)是一种抗有丝分裂剂,通过结合β−−微管蛋白,阻止两对链间二硫键之一的形成,进而抑制微管动力学、破坏有丝分裂纺锤体功能和片段化高尔基复合体来解聚微管。诺考达唑将细胞周期阻滞在G2/M期,也阻止T细胞抗原受体的磷酸化并抑制其活性。在一些正常和肿瘤细胞系中,诺考达唑刺激微管蛋白内在GTP酶活性,激活JNK/SAPK信号传导通路和诱导凋亡。诺考达唑增强CRISPR同源重组修复(HDR)效率和加强Cas9介导的编辑频率。

外形

颜色从白色到淡黄色和粉红色

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Muta. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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