所有图片(1)

文件

M1445

Anti-Mus81 antibody, Mouse monoclonal

clone MTA30 2G10/3, purified from hybridoma cell culture

所有图片(1)

别名:

Anti-SLX3

MDL编号:

MFCD08705592

NACRES:

NA.41

生物来源

mouse

质量水平

200

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

MTA30 2G10/3, monoclonal

形式

buffered aqueous solution

分子量

antigen ~59 kDa

species reactivity

human, monkey

technique(s)

immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using HEK-293T total cell extract

同位素/亚型

IgG2a

UniProt登记号

Q96NY9

运输

dry ice

储存温度

−20°C

Gene Information

human ... MUS81(80198)

比较类似商品

查看完整比较结果

Show Differences

1 of 4

此商品	SAB1411928	SAB4200317	M2444
Sigma-Aldrich M1445 Anti-Mus81 antibody, Mouse monoclonal	Sigma-Aldrich SAB1411928 ANTI-MUS81 antibody produced in mouse	Sigma-Aldrich SAB4200317 Anti-OS9 antibody, Mouse monoclonal	Sigma-Aldrich M2444 Anti-MDC1 antibody, Mouse monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture
clone MTA30 2G10/3, monoclonal	clone polyclonal	clone OS9-8, monoclonal	clone MDC1-50, monoclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt antigen ~59 kDa	mol wt antigen 61.1 kDa	mol wt antigen ~97/88 kDa	mol wt antigen ~250 kDa (2-3 bands)

一般描述

Monoclonal Anti-Mus81 (mouse IgG2a isotype) is derived from the hybridoma MTA30 2G10/3 produced by the fusion of mouse myeloma cells (Sp2/0 Ag.14 cells) and splenocytes from BALB/c mice immunized with Mus81 protein. Crossover junction endonuclease Mus81 protein was identified by screening a human cerebellum cDNA library with a probe from the yeast Mus81. The human Mus81 has 551 amino acids with a molecular mass of 59 kDa. The highest sequence similarity between different species is around the VERKX3D motif. This motif is conserved in the endonuclease family (XPF) family of nucleases. The protein has helix-hairpin-helix DNA-binding domains in the N- and C-termini of the protein that are also conserved.

免疫原

Mus81 protein.

应用

Anti-Mus81 antibody, Mouse monoclonal has been used in immunofluorescence, immunoblotting and immunoprecipitation.

生化/生理作用

Crossover junction endonuclease Mus81 is elevated in cells exposed to agents that block DNA replication. Knockout mice that are homozygous Mus81-/-, or their heterozygous cohorts Mus81-/+, are susceptible to spontaneous chromosomal damage and cancer predisposition suggesting that this protein is important for genomic integrity and tumor suppression

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

如何查找产品货号

在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保在“产品编号”字段中仅输入产品编号 (示例 T1503).

示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

请输入1.000309185)

遇到问题？欢迎随时联系我们技术服务寻求帮助

如何查找COA批号

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich 产品

如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
如果您查询到的批号含有填充代码（例如 STBB0728K9），请输入去除填充代码K9的批号：STBB0728。

未找到您寻找的产品？

部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.

Antonio Porro et al.

Nature communications, 8(1), 1073-1073 (2017-10-21)

Interstrand cross-link (ICL) hypersensitivity is a characteristic trait of Fanconi anemia (FA). Although FANCD2-associated nuclease 1 (FAN1) contributes to ICL repair, FAN1 mutations predispose to karyomegalic interstitial nephritis (KIN) and cancer rather than to FA. Thus, the biological role of

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

Kim Y, et al.

Blood, 121(1), 54-63 (2013)

Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions

Garner E, et al.

Testing, 5(1), 207-215 (2013)

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Neelsen KJ, et al.

The Journal of Cell Biology, 200(6), 699-708 (2013)

Human Mus81-associated endonuclease cleaves Holliday junctions in vitro

Chen XB, et al.

Molecular Cell, 8(5), 1117-1127 (2001)

查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件