Merck

M4439

Sigma-Aldrich

Anti-c-Myc抗体,小鼠单克隆 小鼠抗

clone 9E10, purified from hybridoma cell culture

别名:
抗-c-Myc
NACRES:
NA.56

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

9E10, monoclonal

形式

buffered aqueous solution

分子量

62 kDa

species reactivity

human

浓度

~2 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:5000 using c-myc tagged fusion protein

UniProt登记号

运输

dry ice

储存温度

−20°C

Gene Information

human ... MYC(4609)

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此商品
B7554SAB4501941WH0004609M2
conjugate

unconjugated

conjugate

biotin conjugate

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

9E10, monoclonal

clone

9E10, monoclonal

clone

polyclonal

clone

1G7, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

62 kDa

mol wt

-

mol wt

antigen 48 kDa

mol wt

-

一般描述

V-Myc(v-myc禽髓细胞瘤病病毒致癌基因同源物)是一种转录因子,其由MYC基因编码。它最初被描述为禽逆转录病毒致癌基因的同源物。它属于转录因子家族,以碱性区螺旋-环-螺旋/亮氨酸拉链为特征。它与N-Myc和L-Myc一起构成原癌基因家族。它与MAX形成异二聚体,该二聚体与DNA上的E-boxes/CACGTG基序相结合。该基因位于人染色体8q24上。
小鼠抗c-Myc单克隆抗体可识别位于人类致癌基因c-myc产物序列(EQKLISEEDL)内的表位。

免疫原

人p62c-Myc蛋白的合成肽。

应用

小鼠产生的单克隆抗c-Myc抗体适用于免疫沉淀、 免疫印迹、 酶联免疫吸附分析(ELISA)、免疫荧光、 微阵列和电子显微。它也被应用于ChIP(染色质免疫沉淀)。

生化/生理作用

V-myc禽髓细胞瘤病病毒致癌基因同源物属于MYC家族。当这些蛋白过表达时,可导致DNA双链断裂(DSBs)和基因组不稳定。转录因子MYC有助于调节长链非编码RNA(lncRNAs),后者与癌细胞增殖和肿瘤发生有关。它的过表达也与各种癌症有关,尤其是B细胞淋巴瘤。c-MYC表达的增加对B细胞淋巴瘤向CD4+ T细胞功能表达Ags/肽的能力有负面影响。该蛋白在Ag表达的几个关键点发挥抑制作用。它与Burkitt淋巴瘤和一组弥漫性巨大B细胞淋巴瘤(DLBCL)有关。

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

制备说明

工作稀释液:1:5000

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable


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Susanna Ambrosio et al.
Mutation research, 774, 6-13 (2015-03-17)
Although it is established that when overexpressed, the MYC family proteins can cause DNA double-stand breaks (DSBs) and genome instability, the mechanisms involved remain unclear. MYC induced genetic instability may result from increased DNA damage and/or reduced DNA repair. Here
Željka Škunca et al.
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 68(3), 299-305 (2015-05-29)
Diffuse large B-cell lymphoma (DLBCL) is classified as lymphoma and various entities using the gene expression of proteins are classified into three groups. The aim of this study was to clarify the clinical, biological, immunophenotypic and cytogenetic features of DLBCL
Taewan Kim et al.
Journal of the National Cancer Institute, 107(4), doi:10-doi:10 (2015-02-11)
The functions of long noncoding RNAs (lncRNAs) have been identified in several cancers, but the roles of lncRNAs in colorectal cancer (CRC) are less well understood. The transcription factor MYC is known to regulate lncRNAs and has been implicated in
Mirjana Macvanin et al.
Journal of bacteriology, 194(22), 6046-6055 (2012-09-04)
Some unidentified RNA molecules, together with the nucleoid protein HU, were suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved protein known for its role in binding to DNA and maintaining negative supercoils in
Jonas O Carlsten et al.
Molecular and cellular biology, 32(19), 4035-4043 (2012-08-02)
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A(Cnp1), which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (Pol II)

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