M5539

Sigma-Aldrich

Anti-Macrophage Inflammatory Protein-2 antibody produced in goat

affinity isolated antibody, lyophilized powder

别名:
Anti-MIP-2
MDL number:
NACRES:
NA.41

Quality Level

biological source

goat

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

application(s)

indirect ELISA: suitable
neutralization: suitable
western blot: suitable

conjugate

unconjugated

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Cxcl2(20310)

General description

Macrophage Inflammatory Protein-2 belongs to the C-X-C family of chemokines and acts as chemoattractant for neutrophils. MIP-2 was originally identified as heparin-binding protein secreted in response to endotoxin. This chemokine acts majorly to induce influx of neutrophils following infection by pneumococci, hypersensitive reaction to viral antigen and inflammation due to glomerular nephritis. Pulmonary introduction of LPS results in rapid increase in the levels of MIP-2 producing inflammation. Anti-Macrophage Inflammatory Protein-2 antibody is specific for mouse MIP-2.

Specificity

The antibody shows <5% cross-reactivity with recombinant human GROα, recombinant human GROβ and recombinant human GROγ.

Immunogen

recombinant mouse MIP-2 expressed in E. coli.

Application

Anti-Macrophage Inflammatory Protein-2 antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting, antibody concentration of 0.1-0.2 μg/ml is recommended. The antibody is suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

A B Lentsch et al.
Hepatology (Baltimore, Md.), 27(4), 1172-1177 (1998-04-16)
Hepatic injury induced by ischemia and reperfusion is an important clinical problem after liver resection or transplantation. Neutrophils are known to mediate the organ injury, but the precise mechanisms leading to hepatic neutrophil recruitment are undefined. Two CXC chemokines, macrophage...
Terrence M Tumpey et al.
Journal of virology, 76(16), 8050-8057 (2002-07-23)
BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at...
John B Zamjahn et al.
American journal of physiology. Lung cellular and molecular physiology, 301(4), L568-L574 (2011-07-12)
Previously we showed that cytokine-induced neutrophil chemoattractant (CINC), but not macrophage inflammatory protein-2 (MIP-2), is detected in plasma after intratracheal challenge with LPS or the particular chemokines. To further understand the differences between CINC and MIP-2 flux from the lung...
S D Wolpe et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(2), 612-616 (1989-01-01)
In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes....
Huyu Lin et al.
Aging, 12(13), 12684-12702 (2020-07-07)
Long non-coding RNAs (lncRNAs) have been largely reported to contribute to the development and progression of abdominal aortic aneurysm (AAA), a common vascular degenerative disease. The present study was set out with the aim to investigate the possible role of...

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