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M6751

5-甲基胞嘧啶盐酸盐

≥99%

所有图片(3)

别名:

4-氨基-2-羟基-5-甲基嘧啶

Empirical Formula (Hill Notation):

C₅H₇N₃O · HCl

CAS号:

58366-64-6

分子量:

161.59

EC 号:

261-223-9

MDL编号:

MFCD11053426

PubChem化学物质编号:

24897110

NACRES:

NA.51

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此商品	C3506	I2127	I6875
Sigma-Aldrich M6751 5-甲基胞嘧啶盐酸盐	Sigma-Aldrich C3506 胞嘧啶	Sigma-Aldrich I2127 Isocytosine	Sigma-Aldrich I6875 5-Iodocytosine
assay ≥99%	assay ≥99%	assay ≥99%	assay ≥99% (TLC)
form crystalline powder	form powder	form powder	form powder
solubility water: 50 mg/mL, clear to slightly hazy, colorless	solubility 0.5 M HCl: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow	solubility acetic acid: 50 mg/mL, clear, colorless	solubility formic acid: 50 mg/mL
Quality Level 200	Quality Level -	Quality Level -	Quality Level -

应用

5-甲基胞嘧啶盐酸盐已被用作高效液相色谱（HPLC）法估计整体甲基化率的标准品。它还被用于高分辨率质谱分析。

5-甲基胞嘧啶被用于DNA甲基化过程（表观遗传学）的研究。

生化/生理作用

5-甲基胞嘧啶可介导基因表达、基因组印记和转位因子的抑制。它与翻译保真度和tRNA识别密切相关。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.

Daniel Renciuk et al.

Nucleic acids research, 41(21), 9891-9900 (2013-08-22)

5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito S, et al.

Science (New York, N.Y.), 333(6047), 1300-1303 (2011)

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Squires JE, et al.

Nucleic Acids Research, 40(11), 5023-5033 (2012)

Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry

Lowenthal MS, et al.

Analytical Chemistry, 6, 824-824 (2019)

Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos.

Lan Jiang et al.

Cell, 153(4), 773-784 (2013-05-15)

5-methylcytosine is a major epigenetic modification that is sometimes called "the fifth nucleotide." However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes, including zebrafish gametes and early embryos.

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5-甲基胞嘧啶盐酸盐

≥99%

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