M7820

Monoclonal Anti-MAGE-C1 小鼠抗

clone CT7-33, purified from hybridoma cell culture

• 别名: Anti-CT7, Monoclonal Anti-TAF40/42
• NACRES: NA.41

属性

• 生物来源: mouse
• 质量水平: 200
• 偶联物: unconjugated
• 抗体形式: purified immunoglobulin
• antibody product type: primary antibodies
• 克隆: CT7-33, monoclonal
• 形式: buffered aqueous solution
• 分子量: antigen ~180 kDa
• species reactivity: human
• 浓度: ~1 mg/mL
• technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1-2 μg/mL using total cell extract of SKML37 cells
• 同位素/亚型: IgG1
• UniProt登记号: O60732
• 运输: dry ice
• 储存温度: −20°C
• Gene Information: human ... MAGEC1(9947)

说明

一般描述

Anti-MAGE-C1 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma CT7-33 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-C1. The first melanoma-associated antigen (MAGE) to be identified was MAGE-A1. The MAGE family of proteins contains over 25 genes that have now been identified in human. These proteins share a homologous region, named the MAGE homology domain (MHD).

MAGE family member C1 (MAGE-C1) belongs to the melanoma antigen gene (MAGE) family and consists of 1142 amino acids. The gene encoding MAGE-C1 is localized on human chromosome Xq26-27 and has four exons.

免疫原

human recombinant MAGE-C1.

应用

• Anti-MAGE-C1 antibody, Mouse monoclonal has been used in:
• enzyme-linked immunosorbent assay (ELISA)
• immunocytochemistry
• immunoblotting
• immunoprecipitation
• immunohistochemistry

生化/生理作用

Although the physiological role of melanoma-associated antigen (MAGE) proteins is unknown, it has been reported that MAGE-C1 interacts and co-localizes with an additional cancer testis antigen, NY-ESO-1, in melanoma cells.

MAGE family member C1 (MAGE-C1) has been studied as the most expressed cancer or testis antigen in multiple myeloma.

目标描述

MAGE-C1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)