M8644

Sigma-Aldrich

抗 小鼠 IgM(μ-链特异性) 山羊抗

affinity isolated antibody, lyophilized powder

MDL number:
NACRES:
NA.46

Quality Level

biological source

goat

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

application(s)

indirect ELISA: suitable

conjugate

unconjugated

storage temp.

2-8°C

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General description

小鼠血清来源的 IgM 可作为引用抗原、标准品、封闭剂或包被蛋白用于包括 ELISA、斑点免疫结合、免疫印迹、免疫扩散和免疫电泳在内的多种免疫测定。其他应用包括:用于制备免疫原和固相免疫吸附剂的起始物料。
免疫球蛋白 M (IgM) 抗体在感染早期出现。IgM 抗体是造成不匹配输血中红细胞凝集的原因。IgM 的级别可随疾病状态感染的状态而变化。

Specificity

山羊多克隆抗小鼠 IgM(μ-链特异性)抗体与小鼠 IgM 的 m 链反应。当对照纯化的小鼠 IgA、IgG1、IgG2a、IgG2b、IgG3 和 IgM 骨髓瘤蛋白进行检测时,其对小鼠 IgM 具有特异性。

Application

成功使用该抗体的应用以及相关同行评审论文如下所示。
染色质免疫沉淀(1 篇论文)
酶联免疫分析 (1 篇论文)
山羊多克隆抗小鼠 IgM(μ-链特异性)抗体可用于在体外和通过免疫化学或免疫组织学技术对人血清或其他生物体液中小鼠 IgM 的级别进行鉴别和定量。

Physical form

从 0.01 M 磷酸钠、0.015 M 氯化钠 (pH 7.2) 冻干

Reconstitution

用 0.135 M 氯化钠复溶。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Yasmine Zouggari et al.
Nature medicine, 19(10), 1273-1280 (2013-09-17)
Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the...
D E Macfarlane et al.
Journal of immunology (Baltimore, Md. : 1950), 160(3), 1122-1131 (1998-05-07)
Phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses. We report that quinacrine, chloroquine, and structurally related compounds completely inhibit the antiapoptotic effect of CpG-ODN on WEHI 231 murine B lymphoma cells and inhibit CpG-ODN-induced secretion of IL-6 by WEHI 231....
D E Macfarlane et al.
Immunology, 91(4), 586-593 (1997-08-01)
Certain oligodeoxynucleotides (ODN) containing cytosine followed by guanosine (CpG) protect B cells from apoptosis, and induce B-cell proliferation and cytokine production. We investigated the effect of phosphorothioate CpG-containing ODNs (5'-ATAATCGACGTTCAAGCAAG-3' or 5'-TCCATGACGTTCCTGACGTT-3') and control ODNs (which did not contain CpG)...
Andrew Elvington et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4640-4647 (2012-10-03)
There is mounting evidence indicating an important role for complement in the pathogenesis of cerebral ischemia-reperfusion injury, or ischemic stroke. The role of the alternative complement pathway in ischemic stroke has not been investigated, and there is conflicting data on...
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