Merck
  • M8699
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M8699

Sigma-Aldrich

(R)-MG132

All Photos(1)
Synonym(s):
Z-L-Leu-D-Leu-L-Leu-al
Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
1211877-36-9
Molecular Weight:
475.62

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测定

≥98%

质量水平

200

溶解性

DMSO or DMF: 25 mg/mL

储存温度

−20°C

SMILES string

CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O

应用

(R)-MG132已被用于泛素化测定并用作蛋白酶体抑制剂。

包装

1 mg

生化/生理作用

MG132(carbobenzoxy-Leu-Leu-leucinal)是一种三肽醛。它具有抗肿瘤活性，可增强化疗和放疗的细胞抑制/细胞毒性作用。(R)-MG132是一种有效的膜渗透性蛋白酶体抑制剂。它可以抑制J558L多发性骨髓瘤细胞和EMT6乳腺癌细胞裂解物中的蛋白酶体活性。与(S)-MG132相比，(R)-MG132立体异构体是更有效的胰凝乳蛋白酶样（ChTL）、胰蛋白酶样（TL）和肽酰谷氨酰肽水解蛋白酶体（PGPH）活性抑制剂。

外形

结晶固体或过冷液体

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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