所有图片(3)

N0636

Sigma-Aldrich

烟酰胺

BioReagent, suitable for cell culture, suitable for insect cell culture

别名:
吡啶-3-甲酰胺, 烟酰胺, 维生素 B3, 烟碱酰胺, 维生素 PP
Empirical Formula (Hill Notation):
C6H6N2O
CAS号:
分子量:
122.12
Beilstein:
383619
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.75

质量水平

200

生物来源

synthetic (organic)

产品线

BioReagent

测定

≥98% (HPLC)

形式

powder

分子量

Mw 122.12 g/mol

应用

cell culture | insect: suitable
cell culture | mammalian: suitable

颜色

white

mp

128-131 °C (lit.)

溶解性

water: soluble 50 mg/mL, clear, colorless

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

正在寻找类似产品? Visit 产品对比指南

相关类别

一般描述

烟酰胺(NAM)属于维生素B家族,是微生物B3的酰胺形式。烟酰胺存在于食物中,是烟酰胺腺嘌呤二核苷酸(NAD)和烟酰胺腺嘌呤二核苷酸磷酸(NADP)的组分这一。色氨酸是肝脏中合成NAM的前体。NAM控制细胞代谢,氧化反应,线粒体功能和能量产生。它促进天然杀手细胞增生和生存。NAM有神经保护功能,促进神经元成熟。它能够跨越血脑屏障,在缺血性中风和创伤性脑损伤中提供保护。NAM可能对于阿尔兹海默症,帕金森症和亨廷顿病有治疗作用。

应用

烟酰胺用于肠道干细胞类器官培养,食管鳞状细胞癌(ESCC),胰腺肿瘤类器官和胰腺祖细胞诱导培养基补充剂。

包装

100, 500 g in poly bottle

生化/生理作用

烟酰胺是维生素B3的酰胺衍生物,是PARP抑制剂

象形图

Exclamation mark

警示用语:

Warning

危险声明

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 1

闪点(F)

302.0 °F - closed cup

闪点(C)

150 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

原产地证书 (CofO)

Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells
Kijima T, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 73-91 (2019)
The influence of nicotinamide on health and disease in the central nervous system
Fricker RA, et al.
International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)
Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors
Romero-Calvo I, et al.
Molecular Cancer Research, molcanres-molca0531 (2018)
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture
Hosic S, et al.
bioRxiv, 400721-400721 (2018)

技术文章

Mitochondrial Stress and ROS

Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

相关内容

线粒体应激和ROS

氧化应激,在一部分上,是由多种细胞过程产生的活性氧介导,并由诸如酶清除剂或抗氧化剂调节剂等细胞抗氧化剂机制所控制的。自由基,如活性氧,会通过细胞引起细胞损伤。

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门