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Merck

N8523

Sigma-Aldrich

Monoclonal Anti-NF-κB antibody produced in mouse

clone NF-12, ascites fluid

别名:

Anti-CVID12, Anti-EBP-1, Anti-KBF1, Anti-NF-kB, Anti-NF-kB1, Anti-NF-kappa-B1, Anti-NF-kappaB, Anti-NF-kappabeta, Anti-NFKB-p105, Anti-NFKB-p50, Anti-NFkappaB

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

ascites fluid

抗體產品種類

primary antibodies

無性繁殖

NF-12, monoclonal

分子量

antigen 65 kDa

包含

15 mM sodium azide

物種活性

human, mouse

技術

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a whole cell extract from a mouse fibroblast cell line

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NFKB1(4790)
mouse ... Nfkb1(18033)

一般說明

Monoclonal Anti-NF-κB p65 (mouse IgG1 isotype) is derived from the NF-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a recombinant, mouse NF-κB p65 fragment. Nuclear factor κB (NF-κB1) is a member of NF-κB/Rel family of transcription factors.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) is a subunit of nuclear factor κB (NF-κB) and exists as a dimer. It is expressed in the cytosol.

免疫原

recombinant mouse NF-κB p65 fragment (C-terminal, 151 amino acids).

應用

Monoclonal Anti-NF-κB antibody produced in mouse has been used in immunohistochemistry and Western blotting.

生化/生理作用

Nuclear factor kappa-B (NF-κB1) has an ability to affect transcription of κB reporter genes positively or negatively when assayed following transfection.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) has a role in hippocampal neurogenesis. It regulates the signaling by nuclear factor κB (NF-κB). Deletion of the gene in mice leads to defects in innate and adaptive immunity. The protein acts as a mediator of apoptotic response to S-phase DNA damage and replication stress. NFKB1 modulates the structural plasticity of cortical neurons. Knockout of the protein in mice has been shown to cause liver apoptosis and embryonic death.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions
Caamano J and Hunter C A
Clinical Microbiology Reviews, 15(3), 414-429 (2002)
Cheng Lin et al.
Experimental and therapeutic medicine, 11(4), 1355-1360 (2016-04-14)
The aim of the current study was to observe the effects of simvastatin and taurine on delayed cerebral vasospasm (DCVS) following experimental subarachnoid hemorrhage (SAH) in rabbits. A total of 48 New Zealand white rabbits were allocated at random into
Min Hu et al.
International journal of clinical and experimental pathology, 11(4), 2072-2079 (2018-04-01)
In the establishment and continuation of a successful pregnancy, the proliferation, migration, and invasion of trophoblast cells play essential roles. Impaired trophoblast function has been reported to be involved in recurrent spontaneous abortion (RSA) but the potential mechanisms are still
Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice
Sara Anna Bonini
Cerebral Cortex, 26(6), 2832?2849-2832?2849 (2016)
Effects of simvastatin and taurine on delayed cerebral vasospasm following subarachnoid hemorrhage in rabbits
Cheng Lin
Experimental and Therapeutic Medicine, 1355-1360 (2016)

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