O4636

土霉素 二水合物

Assay (anhydrous basis) 95.0%-102.0%

• Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₉ · 2H₂O
• CAS号: 6153-64-6
• 分子量: 496.46
• EC 号: 201-212-8
• MDL编号: MFCD00151234
• PubChem化学物质编号: 24898000
• NACRES: NA.85

属性

• 质量水平: 200
• 作用机制: protein synthesis | interferes
• 抗生素抗菌谱: Gram-negative bacteria; Gram-positive bacteria
• SMILES string: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
• InChI key: IBZHEBHGZFICKS-IFLJXUKPSA-N

说明

一般描述

Chemical structure: tetracycline

应用

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is indicated for treatment of infections caused by microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

生化/生理作用

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

分析说明

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

其他说明

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 象形图: GHS08,GHS09
• 警示用语：: Warning
• 危险声明: H361d - H411
• 预防措施声明: P201 - P202 - P273 - P280 - P308 + P313 - P391
• 危险分类: Aquatic Chronic 2 - Repr. 2
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)