biological source
rabbit
Quality Level
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
(Pseudomonas aeruginosa)
application(s)
dot blot: 1:20,000
indirect ELISA: 1:250,000
conjugate
unconjugated
shipped in
dry ice
storage temp.
−20°C
General description
可与假单胞菌外毒素A发生反应，但对葡萄球菌肠毒素A、霍乱毒素和葡萄球菌肠毒素B无反应。该产品尚未检测过对活性假单胞菌外毒素A的中和效力。
Immunogen
来源于铜绿假单胞菌的外毒素A。
Application
兔抗假单胞菌外毒素A抗体可用于：
- 血清融合毒素的体外稳定性分析
- 构建靶向表皮生长因子受体（EGFR）的毒素，以研究其对转染人EGFR的Swiss小鼠胚胎NIH-3T3细胞的毒性
- 测定血清中免疫毒素的体内半衰期
抗假单胞菌外毒素A抗体可用于融合毒素的体外血清稳定性和靶向毒素的结合研究。
Biochem/physiol Actions
铜绿假单胞菌外毒素A由铜绿假单胞菌分泌，具有较强的细胞毒性作用。外毒素A通过受体介导的内吞作用进入细胞，转运到细胞质，通过ADP核糖化因子2抑制蛋白质合成。嵌合外毒素A在各种疾病的基因治疗和可能的癌症治疗中都有应用。
Physical form
本产品是含有15 mM 叠氮化钠防腐剂的液体。
Storage and Stability
如需连续使用，可在2-8 °C保存至多一月。对于更长期的存储，可对溶液进行等分并冷冻保存。不建议反复冻融。不建议在无霜冰箱中储存。如果长期储存后发生轻微浑浊，请在使用前通过离心澄清溶液。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
RIDADR
NONH for all modes of transport
WGK Germany
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
分析证书
原产地证书 (CofO)
Fusion of an albumin-binding domain extends the half-life of immunotoxins
Guo R, et al.
International Journal of Pharmaceutics, 511(1), 538-549 (2016)
Alexander Weng et al.
Molecular oncology, 6(3), 323-332 (2012-02-09)
Tumor-targeting protein toxins are composed of a toxic enzyme coupled to a specific cell binding domain that targets cancer-associated antigens. The anti-tumor treatment by targeted toxins is accompanied by dose-limiting side effects. The future prospects of targeted toxins for therapeutic...
Characterization of an HLA-restricted and human cytomegalovirus-specific antibody repertoire with therapeutic potential.
Bewarder, et al.
Cancer Immunology, Immunotherapy, 69, 1535-1548 (2020)
Alexander N Wein et al.
Journal of medicinal chemistry, 55(18), 7998-8006 (2012-09-08)
Protective antigen (PA), lethal factor, and edema factor, the protein toxins of Bacillus anthracis , are among its most important virulence factors and play a key role in infection. We performed a virtual ligand screen of a library of 10000...
Yi Hu et al.
Leukemia research, 35(9), 1254-1260 (2011-02-08)
We have previously demonstrated that CCR9 plays a pivotal role in drug resistance and invasion in human acute T-lymphocytic leukemia (T-ALL). In this study, we investigated whether the MOLT4 cells, which naturally express CCR9 at high levels, can be successfully...
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门社交媒体
Merck
科研、开发、生产。
作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。
