P8139

Sigma-Aldrich

佛波醇12-十四酸酯13-乙酸酯

≥99% (TLC), film or powder

别名:
PMA, TPA, 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯, 12-O-十四烷酰基佛波醇13-乙酸酯
Empirical Formula (Hill Notation):
C36H56O8
CAS号:
分子量:
616.83
Beilstein/REAXYS Number:
2407201
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

测定

≥99% (TLC)

形式

film or powder

溶解性

DMSO: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.)
ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)

储存温度

−20°C

SMILES string

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-RGYGYFBISA-N

正在寻找类似产品? Visit 产品对比指南

一般描述

佛波醇12-肉豆蔻酸酯13-乙酸酯是一种佛波酯。它可作为肿瘤促进因子并通过蛋白激酶C(PKC)信号通路参与基因转录、细胞生长、分化、程序性细胞死亡、免疫途径和受体脱敏。佛波醇12-肉豆蔻酸酯13-乙酸酯还是一种研究生长因子、激素和细胞因子介导的细胞生长和分化调控的模范试剂。

应用

佛波醇12-肉豆蔻酸酯13-乙酸酯已用于刺激多种细胞,包括脾细胞、静息淋巴细胞和胎儿胸腺细胞。它还用于细胞中PKC(蛋白激酶C)的激活。

生化/生理作用

有效的肿瘤促进剂;在体内体外激活蛋白激酶C。

特点和优势

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。如需浏览其他手册页面,请点击此处
该化合物还作为Sigma药理活性化合物库(LOPAC®1280)中的一部分进行提供,而这是一个具有生物学注释的高品质即用型的筛选化合物集合。 点击此处 以了解更多。

注意

光敏感的

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

警示用语:

Danger

hazcat

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

原产地证书 (CofO)

  1. What is the difference between Phorbol 12-myristate 13-acetate, Product P8139 and molecular biology grade Product P1585?

    Product P1585 has been tested and found suitable for stimulation of interleukin 2 production of Jurkat cells. Product P8139 has not tested in this application.

  2. Why do I not see any solid in the Phorbol 12-myristate 13-acetate bottle, Product P8139?

    Phorbol 12-myristate 13-acetate may be an invisible film in the bottle.

  3. How should Product P8139, Phorbol 12-myristate 13-acetatebe dissolved?

    Stock solutions of 20 mM can be prepared in DMSO and diluted into aqueous buffers. View more information on P8139 solubility in the product information sheet (under Documents, above).

  4. How should I store the solutions of Product P8139, Phorbol 12-myristate 13-acetate?

    Stock solutions in DMSO can be stored protected from light as aliquots at -20°C for at least 6 months, or at 2-8°C for up to 3 months.

  5. Do you have any application information for Product P8139, Phorbol 12-myristate 13-acetate?

    View the P8139 product information sheet (under Documents, above).

  6. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  7. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Cytokine requirements for the growth and development of mouse NK cells in vitro.
Toomey JA et al.
Journal of Leukocyte Biology, 74, 233-233 (2003)
Inhibition of protein kinase C results in decreased expression of bovine leukemia virus.
Jensen WA et al.
Journal of Virology, 66, 4427-4427 (1992)
NGFI-A gene expression is necessary for T lymphocyte proliferation.
Perez-Castillo A et al.
The Journal of Biological Chemistry, 268, 19445-19445 (1993)
Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Lee HW et al.
The Journal of Biological Chemistry, 277, 32624-32624 (2002)
Liwang Liu et al.
Journal of biophotonics, 12(8), e201900045-e201900045 (2019-05-31)
Advances in microscopy with new visualization possibilities often bring dramatic progress to our understanding of the intriguing cellular machinery. Picosecond optoacoustic micro-spectroscopy is an optical technique based on ultrafast pump-probe generation and detection of hypersound on time durations of picoseconds...
技术文章
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
了解更多

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门