Merck
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P8139

Sigma-Aldrich

佛波醇12-十四酸酯13-乙酸酯

≥99% (TLC), film or powder

Synonym(s):
12-O-十四烷酰基佛波醇13-乙酸酯, 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯, PMA, TPA
Empirical Formula (Hill Notation):
C36H56O8
CAS Number:
Molecular Weight:
616.83
Beilstein:
2407201
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

200

测定

≥99% (TLC)

形式

film or powder

溶解性

DMSO: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.)
ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)

储存温度

−20°C

SMILES string

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-RGYGYFBISA-N

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一般描述

佛波醇12-肉豆蔻酸酯13-乙酸酯是一种佛波酯。它可作为肿瘤促进因子并通过蛋白激酶C(PKC)信号通路参与基因转录、细胞生长、分化、程序性细胞死亡、免疫途径和受体脱敏。佛波醇12-肉豆蔻酸酯13-乙酸酯还是一种研究生长因子、激素和细胞因子介导的细胞生长和分化调控的模范试剂。

应用

佛波醇12-肉豆蔻酸酯13-乙酸酯已用于刺激多种细胞,包括脾细胞、静息淋巴细胞和胎儿胸腺细胞。它还用于细胞中PKC(蛋白激酶C)的激活。

生化/生理作用

有效的肿瘤促进剂;在体内体外激活蛋白激酶C。

特点和优势

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。如需浏览其他手册页面,请点击此处

注意

光敏感的

警示用语:

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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