PHG0001

SAFC

羟乙基哌嗪乙硫磺酸

别名:
4-(2-羟乙基)哌嗪-1-乙磺酸, N-(2-羟乙基)哌嗪-N′-(2-乙磺酸)
Empirical Formula (Hill Notation):
C8H18N2O4S
CAS号:
分子量:
238.30
Beilstein/REAXYS Number:
883043
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.21

质量水平

400

生物来源

synthetic

形式

powder

应用

cell culture | mammalian: suitable

杂质

Endotoxin, microbial, and trace metals; tested

pH值(酸碱度)

4.7-5.3 (, )

有效pH范围

6.8 - 8.2

pKa (25 °C)

7.5

适用性

suitable for manufacturing use

异质活性

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

OCCN1CCN(CC1)CCS(O)(=O)=O

InChI

1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

InChI key

JKMHFZQWWAIEOD-UHFFFAOYSA-N

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包装

100 g in poly bottle
5, 10, 25, 50 kg in poly drum

应用

HEPES是一种生物缓冲液,通常被称为“好”缓冲液。它是最常用的生物缓冲液,因为HEPES的pKa为7.31,与生理pH值7.36相对应。HEPES被认为是对培养细胞系无毒的一种物质,高度可溶于水并可为溶液提供高澄清度。

HEPES用于细胞培养基、生物制药缓冲制剂(上游和下游)以及诊断试剂。基于HEPES的缓冲液被用于纯化抗体、生物活性物质、蛋白质和生长因子的生物过程。

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

P Dey et al.
Oncogene, 33(33), 4213-4225 (2013-10-01)
Estrogen receptor β (ERβ) is emerging as a critical factor in understanding prostate cancer biology. Although reduced in prostate cancer above Gleason grade 3, ERβ is a potential drug target at the initial stage of the disease. In human prostate...
Frédéric Perros et al.
Journal of the American College of Cardiology, 65(7), 668-680 (2015-02-14)
Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting vasoconstriction, smooth muscle proliferation, and inflammation. This study sought to test the hypothesis that nebivolol, a β1-antagonist and β2,3-agonist, may improve PAH and...
Brendan M Leung et al.
Journal of tissue engineering and regenerative medicine, 9(11), 1247-1258 (2013-03-19)
Modular cardiac tissues developed both vascular and cardiac structures in vivo, provided that the host response was attenuated by omitting xenoproteins from the modules. Collagen gel modules (with Matrigel(TM)) containing cardiomyocytes (CMs) alone or CMs with surface-seeded endothelial cells (ECs; CM/EC...
Alexandre Albanese et al.
ACS nano, 8(6), 5515-5526 (2014-05-07)
A nanoparticle's physical and chemical properties at the time of cell contact will determine the ensuing cellular response. Aggregation and the formation of a protein corona in the extracellular environment will alter nanoparticle size, shape, and surface properties, giving it...
Bethany L Macleod et al.
PLoS pathogens, 10(8), e1004303-e1004303 (2014-08-15)
Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell effector function in situ remains poorly understood. Here, we show key differences in the regulation of effector activity between CD4+ and CD8+ T-cells...

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