PLA0106

Sigma-Aldrich

Rabbit anti-MSH2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

别名:
FCC1, mutS homolog 2, LCFS2, COCA1, MutS protein homolog 2, HNPCC, nonpolyposis type 1, nonpolyposis type 1 (E. coli), HNPCC1, mutS (E. coli) homolog 2 (colon cancer; nonpolyposis type 1), colon cancer, hMSH2
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human, mouse

application(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:1,000-1:5,000

accession no.

P43246

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... MSH2(4436)

Immunogen

The epitope recognized by PLA0106 maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

分析证书
原产地证书 (CofO)
Raul Alvarado-Bachmann et al.
Molecular medicine reports, 10(2), 1003-1006 (2014-05-27)
Knowledge of the molecular biology of primary colorectal cancer (CRC) has improved in recent years, and one reason for this is the identification of microsatellite instability (MSI), which occurs in up to 15% of sporadic CRC. However, less is known...
Kimberly C Wiegand et al.
Human pathology, 45(6), 1258-1268 (2014-04-29)
ARID1A/BAF250a has been recently implicated as a tumor suppressor in gastric cancer. We sought to clarify the clinical significance of BAF250a/ARID1A in relation to other clinical parameters and relevant biomarkers in gastric carcinoma. Cases from 2 separate cohorts of patients...
Anne-Sophie Bats et al.
Anticancer research, 34(6), 3211-3215 (2014-06-13)
To assess the feasibility of Microsatellite Instability (MSI) analysis in uterine cavity washings for detecting endometrial cancer in Lynch syndrome. This was a proof-of-concept study in Lynch syndrome patients, scheduled for hysterectomy. At the beginning of surgical procedure, uterine cavity...

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