所有图片(3)

Q4951

槲皮素

≥95% (HPLC), solid

所有图片(3)

别名:

3,3′,4′,5,6-五羟基黄酮, 槲皮素

Empirical Formula (Hill Notation):

C₁₅H₁₀O₇

CAS号:

117-39-5

分子量:

302.24

Beilstein:

317313

EC 号:

204-187-1

PubChem化学物质编号:

329823865

生物来源

synthetic (organic)

质量水平

100

测定

≥95% (HPLC)

形式

solid

mp

316.5 °C

溶解性

water: practically insoluble

储存温度

room temp

SMILES string

OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1

InChI

1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

InChI key

REFJWTPEDVJJIY-UHFFFAOYSA-N

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应用

槲皮素是一种抗氧化剂，可逆转2型糖尿病患者高血糖和高血糖血清的免疫抑制作用。
它已被用作 欧洲黑蜂的一种解毒植物化学物质。
它被用作DPPH(2,2-二苯基-1-苦肼)自由基清除实验中的阳性对照。它还可用于制作总黄酮含量测定的校准曲线。

包装

10, 100 g in glass bottle

生化/生理作用

槲皮素是一种具有抗癌活性的黄酮类化合物。槲皮素是一种线粒体ATP酶和磷酸二酯酶抑制剂。它抑制PI3激酶活性，并略抑制PIP激酶活性。槲皮素对癌细胞具有抗增殖作用，通过II型雌激素受体降低癌细胞生长，并在细胞周期G1晚期抑制人白血病T细胞。槲皮素还可能抑制脂肪酸合酶活性。

特点和优势

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。要浏览其他手册页面，请单击此处。

该化合物是ADME毒素和激酶磷酸酶的特色产品。点击这里以发现更多ADME Tox 和激酶磷酸酶生物学特色产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P264 - P270 - P301 + P310 - P405 - P501

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书

请输入批号搜索分析证书（COA）。

原产地证书 (CofO)

请输入批号搜索原产地证书（COO）。

Quotes and Ordering

Bulk Quote-Order Product

Phenolic and flavonoid content and antioxidants capacity of pressurized liquid extraction and perculation method from roots of Scutellaria pinnatifida A. Hamilt. subsp alpina (Bornm) Rech. f.

Golmakani E et al.

Journal of Supercritical Fluids, 95, 318-324 (2014)

Exhausted Woods from Tannin Extraction as an Unexplored Waste Biomass: Evaluation of the Antioxidant and Pollutant Adsorption Properties and Activating Effects of Hydrolytic Treatments.

Lucia Panzella et al.

Antioxidants (Basel, Switzerland), 8(4) (2019-04-04)

Exhausted woods represent a byproduct of tannin industrial production processes and their possible exploitation as a source of antioxidant compounds has remained virtually unexplored. We herein report the characterization of the antioxidant and other properties of practical interest of exhausted

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/?-catenin and p38 MAPK.

Gilardini Montani MS et al.

Biochimica et Biophysica Acta, 1862, 805-805 (2016)

Specific localization of quercetin-3-O-glucuronide in human brain.

Akari Ishisaka et al.

Archives of biochemistry and biophysics, 557, 11-17 (2014-06-04)

In recent years, many papers have suggested that dietary flavonoids may exert beneficial effects in the brain tissue for the protection of neurons against oxidative stress and inflammation. However, the bioavailability of flavonoids across the blood-brain barrier and the localization

Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection.

Anand Kumar Pandey et al.

International review of neurobiology, 102, 107-146 (2012-07-04)

Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging-related brain disorders. This review is focused on

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