Merck

R8875

Sigma-Aldrich

鱼藤酮

≥95%

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Empirical Formula (Hill Notation):
C23H22O6
CAS号:
分子量:
394.42
Beilstein:
6773081
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥95%

bp

210-220 °C/0.5 mmHg (lit.)

mp

159-164 °C (lit.)

SMILES string

COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C

InChI

1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1

InChI key

JUVIOZPCNVVQFO-HBGVWJBISA-N

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此商品
SMB0060445656557368
Rotenone ≥95%

Sigma-Aldrich

R8875

鱼藤酮

Bakuchiol ≥95%

Sigma-Aldrich

SMB00604

补骨脂酚

Rotenone PESTANAL®, analytical standard

Supelco

45656

鱼藤酮

Rotenone A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain.

Sigma-Aldrich

557368

Rotenone

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

bp

210-220 °C/0.5 mmHg (lit.)

bp

-

bp

210-220 °C/0.5 mmHg (lit.)

bp

-

mp

159-164 °C (lit.)

mp

-

mp

159-164 °C (lit.)

mp

-

一般描述

鱼藤酮属于类视黄醇家族。它天然存在于豆科植物中,并被认为具有细胞毒性。它常被用作杀虫剂。

应用

鱼藤酮已用于:
  • 研究其对细胞增殖的影响
  • 检测分离的大鼠前脑线粒体中细胞活性氧族的产生
  • 测定线粒体酶活

生化/生理作用

鱼藤酮是烟酰胺腺嘌呤二核苷酸(NADH):泛醌氧化还原酶线上粒体电子传递的一种抑制剂。它能够很容易的通过节肢动物的外骨骼被吸收,但皮肤或哺乳动物的胃肠道的吸收则不佳。鱼藤酮作为一种神经毒素能产生帕金森样症状,从而作为一种动物模型用于作为病因和干预措施的研究。

象形图

Skull and crossbonesEnvironment

警示用语:

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3


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