Merck

S0130

Sigma-Aldrich

链脲菌素

≥75% α-anomer basis, ≥98% (HPLC), powder

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别名:
链脲佐菌素, 链脲霉素
Empirical Formula (Hill Notation):
C8H15N3O7
CAS号:
分子量:
265.22
Beilstein:
2060675
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥75% α-anomer basis
≥98% (HPLC)

形式

powder

颜色

white to light yellow

mp

121 °C (dec.) (lit.)

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

储存温度

−20°C

SMILES string

CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

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572201203709480743
Streptozocin ≥75% α-anomer basis, ≥98% (HPLC), powder

Sigma-Aldrich

S0130

链脲菌素

Streptozotocin An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Millipore

572201

链脲佐菌素

form

powder

form

crystalline solid

form

solid

form

solid

color

white to light yellow

color

off-white to pale yellow

color

orange-yellow

color

off-white

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

mp

121 °C (dec.) (lit.)

mp

-

mp

-

mp

-

一般描述

链脲佐菌素或链脲佐菌素是从不产色链霉菌中获得的。链脲佐菌素是一种葡糖胺-亚硝基脲,是一种仅通过GLUT2葡萄糖转运蛋白进入细胞的DNA烷化剂。链脲菌素,一种致糖尿病剂,对于产生胰岛素的胰岛β-细胞具有特别的毒性。它对GLUT2阳性神经内分泌肿瘤细胞具有毒性。

应用

链脲菌素或链脲佐菌素用于诱导1型糖尿病用于医学研究。

生化/生理作用

一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物;诱导胰岛素分泌细胞的死亡,产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。
临床上,该化合物用于胰腺β细胞癌的治疗。

其他说明

混合的端基异构体

通常也和此产品一起购买

象形图

FlameHealth hazard

警示用语:

Warning

危险声明

危险分类

Carc. 2 - Flam. Sol. 2 - Muta. 2

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice
Sung-Hsun Yu
PLoS ONE (2016)
Housekeeping proteins: How useful are they in skeletal muscle
diabetes studies and muscle hypertrophy models?
Marco
Analytical Biochemistry, 504, 38-40 (2016)
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Recent years have witnessed an increased prevalence of knee osteoarthritis (KOA) among diabetes mellitus (DM) patients-conditions which might share common risk factors such as obesity and advanced aging. Therefore, we conducted dry-to-wet lab research approaches to assess the correlation of
The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources
Melanie L Graham
Comparative Medicine, 61(4), 356-360 (2011)
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