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SAB1402530

单克隆抗-POLQ 小鼠抗

clone 1C11, purified immunoglobulin, buffered aqueous solution

所有图片(2)

别名:

DKFZp781A0112, POLH, PRO0327

NACRES:

NA.41

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此商品	SAB1405227	SAB1404988	SAB1402447
Sigma-Aldrich SAB1402530 单克隆抗-POLQ 小鼠抗	Sigma-Aldrich SAB1405227 Monoclonal Anti-POLD4 antibody produced in mouse	Sigma-Aldrich SAB1404988 Monoclonal Anti-POLA2 antibody produced in mouse	Sigma-Aldrich SAB1402447 Monoclonal Anti-PIGQ antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone 1C11, monoclonal	clone 2C11, monoclonal	clone 2A8, monoclonal	clone 2B7, monoclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt antigen ~38.1 kDa	mol wt antigen ~29.85 kDa	mol wt antigen ~91.89 kDa	mol wt antigen ~36.89 kDa

免疫原

POLQ（NP_006587, 2572 a.a.~ 2680 a.a）带有GST标签的部分重组蛋白。仅GST标签的MW为26 KDa。

序列
DGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRTGLSRKRKLQGMFCPIRGGFFILQLHDELLYE

外形

溶于pH7.4的磷酸盐缓冲盐水中的溶液

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

Jia Zhou et al.

Nature cancer, 2(6), 598-610 (2021-06-29)

DNA polymerase theta (POLθ) is synthetic lethal with Homologous Recombination (HR) deficiency and thus a candidate target for HR-deficient cancers. Through high-throughput small molecule screens we identified the antibiotic Novobiocin (NVB) as a specific POLθ inhibitor that selectively kills HR-deficient

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.

Ruben Schep et al.

Molecular cell, 81(10), 2216-2230 (2021-04-14)

DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combination with Cas9 cutting, we

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文件

单克隆抗-POLQ 小鼠抗

clone 1C11, purified immunoglobulin, buffered aqueous solution

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