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SAB1407780

Anti-MCOLN1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

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别名:

ML4, MLIV, MST080, MSTP080, TRP-ML1, TRPM-L1, TRPML1

NACRES:

NA.41

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此商品	M8072	SAB1405258	SAB1407870
Sigma-Aldrich SAB1407780 Anti-MCOLN1 antibody produced in mouse	Sigma-Aldrich M8072 Anti-Mucolipin-1 antibody, Mouse monoclonal	Sigma-Aldrich SAB1405258 Monoclonal Anti-MARCKSL1, (C-terminal) antibody produced in mouse	Sigma-Aldrich SAB1407870 Anti-MS4A6A antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone polyclonal	clone MLN128, monoclonal	clone 2H5, monoclonal	clone polyclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt antigen ~65 kDa	mol wt antigen ~110 kDa (additional bands may be observed)	mol wt antigen ~35.9 kDa	mol wt antigen ~27.39 kDa

免疫原

MCOLN1 (NP_065394.1, 1 a.a. ~ 580 a.a) full-length human protein.

Sequence
MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

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Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1.

Spooner E, et.al.

PLoS ONE, 8, e56780-e56780 (2013)

Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

Coblentz J, et.al.

The Biochemical Journal, 457, 361-368 (2014)

The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin.

Cao Q, et.al.

The Journal of Biological Chemistry, 292, 8424-8435 (2017)

Regulation of TRPML1 function.

Waller-Evans H and Lloyd-Evans E

Biochemical Society Symposium, 43, 442-446 (2015)

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance.

Shun Li et al.

Nature communications, 10(1), 1693-1693 (2019-04-14)

Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated

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Anti-MCOLN1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

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