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SAB1409846

Monoclonal Anti-CAMK2B antibody produced in mouse

clone S12, purified immunoglobulin, buffered aqueous solution

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别名:

CAM2, CAMK2, CAMKB, MGC29528

NACRES:

NA.41

生物来源

mouse

质量水平

100

偶联物

unconjugated

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

S12, monoclonal

形式

buffered aqueous solution

分子量

antigen 81.07 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable

同位素/亚型

IgG

NCBI登记号

BC019070

UniProt登记号

Q13554

运输

dry ice

储存温度

−20°C

Gene Information

human ... CAMK2B(816)

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此商品	SAB1409845	SAB1403630	SAB1403629
Sigma-Aldrich SAB1409846 Monoclonal Anti-CAMK2B antibody produced in mouse	Sigma-Aldrich SAB1409845 Monoclonal Anti-CAMK2B antibody produced in mouse	Sigma-Aldrich SAB1403630 Monoclonal Anti-CAMK2B antibody produced in mouse	Sigma-Aldrich SAB1403629 Monoclonal Anti-CAMK2A antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone S12, monoclonal	clone 6D6, monoclonal	clone S11, monoclonal	clone 2C12, monoclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt antigen 81.07 kDa	mol wt antigen 36.52 kDa	mol wt antigen ~81.44 kDa	mol wt antigen ~37.66 kDa

一般描述

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. (provided by RefSeq)

免疫原

CAMK2B (AAH19070.1, 1 a.a. ~ 503 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ

生化/生理作用

Calcium/calmodulin dependent protein kinase II β (CAMK2B) may bind to calmodulin. It has been associated with major depressive disorder.

外形

Solution in phosphate buffered saline, pH 7.4

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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Possible inhibitor from traditional Chinese medicine for the ? form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.

Hung TC

BioMed Research International, 761849-761849 (2014)

Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.

Ju Hee Kim et al.

BMB reports, 44(8), 523-528 (2011-08-30)

To identify novel genes that are regulated by promoter methylation, a combinational approach involving in silico mining followed by molecular assay was performed. From the expression microarray data registered in the European bioinformatics institute (EBI), genes showing downregulation in breast

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