Merck

SAB2500803

Sigma-Aldrich

Anti-Plasminogen Activator/PLAU antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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别名:
Anti-ATF, Anti-HGNC:9052, Anti-Plasminogen activator, Anti-UPA, Anti-Urokinase
MDL编号:

生物来源

goat

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

种属反应性

human

技术

indirect ELISA: suitable
western blot: suitable

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... PLAU(5328)

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
HPA008719SAB4200412WH0005340M1
单克隆抗 PLAUR/uPAR 小鼠抗 clone PL231, purified from hybridoma cell culture

SAB4200412

单克隆抗 PLAUR/uPAR 小鼠抗

biological source

goat

biological source

rabbit

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

Gene Information

human ... PLAU(5328)

Gene Information

human ... PLAU(5328)

Gene Information

human ... PLAUR(5329)

Gene Information

human ... PLG(5340)

一般描述

Urokinase-type plasminogen activator is also known as PLAU and uPA. The human uPA is initially synthesized as 431 amino acid precursor with an N-terminal signal peptide (20 residues). The single chain molecule is processed into a disulfide-linked two-chain molecule of different molecular weights. Two forms of the A chain exist, starting at Ser21 (the long form) and Lys156 (the short form). The long and short A chains are unique to the high and low molecular weight forms, respectively. The long A chain contains an EGF (epidermal growth factor)-like domain, responsible for binding of the PLAU receptor. The B chain corresponds to the catalytic domain. The gene encoding it is localized on human chromosome 10.

免疫原

Peptide with sequence C-HFLPWIRSHTKEEN from the C Terminus of the protein sequence according to NP_002649.1.

生化/生理作用

Urokinase-type plasminogen activator is a serine protease with extremely limited substrate specificity, cleaving the sequence Cys-Pro-Gly-Arg560-Val561-Val-Gly-Gly-Cys in plasminogen to form plasmin. It is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Identification of a novel inhibitor of urokinase-type plasminogen activator.
Zhu M
Molecular Cancer Therapeutics, 6(4), 1348-1356 (2007)
Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Yasuda S
Blood, 105(10), 3893-3901 (2005)
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Spraggon G
Structure, 3(7), 681-691 (1995)

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