Merck
All Photos(2)

SAB4200182

Sigma-Aldrich

Anti-Glutathione Reductase antibody, Mouse monoclonal

clone GR6, purified from hybridoma cell culture

All Photos(2)
Synonym(s):
Anti-GR, Anti-GSR, Anti-Glutathione-disulfide reductase, Anti-NADPH:oxidized glutathione oxidoreductase
MDL编号:
MFCD01323367
NACRES:
NA.41

生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

GR6, monoclonal

形式

buffered aqueous solution

分子量

antigen ~55 kDa

species reactivity

human

浓度

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): suitable
western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.

同位素/亚型

IgG1

UniProt登记号

P00390

运输

dry ice

储存温度

−20°C

Gene Information

human ... GSR(2936)

一般描述

Monoclonal Anti-Glutathione Reductase (mouse IgG1 isotype) is derived from the hybridoma GR6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human Glutathione reductase recombinant protein. Glutathione reductase is a homodimeric enzyme containing one FAD molecule and NADPH binding domain per subunit. This gene is located on human chromosome 8p.

免疫原

mice immunized with a human Glutathione reductase recombinant protein. The corresponding proteins in rat and mouse share 86% and 85% homology, respectively.

应用

Monoclonal Anti-Glutathione Reductase antibody produced in mouse has been used in:
  • immunohistochemical
  • immunofluorescence studies
  • immunoblotting
  • immunoprecipitation

生化/生理作用

Glutathione reductase (GR) is a ubiquitous flavoenzyme involved in protecting cells from stress. GR catalyses the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is an essential component of the glutathione redox cycle, which maintains adequate levels of reduced cellular GSH. GSH serves as an antioxidant and also as an electron donor for glutathione peroxidases and a substrate for glutathione-S-transferases.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(F)

Not applicable

闪点(C)

Not applicable

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