Merck

SAB4200398

Sigma-Aldrich

Anti-TFRC antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

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别名:
Anti-CD71, Anti-TFR, Anti-TFR1, Anti-TR, Anti-TRFR, Anti-Transferrin receptor (p90, CD71), Anti-Transferrin receptor protein 1, Anti-p90, AntiT9
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen ~90 kDa

species reactivity

mouse, rat, human

浓度

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 10-20 μg/mL using rat NRK cells
western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... TFRC(7037)
mouse ... Tfrc(22042)
rat ... Tfrc(64678)

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此商品
HPA028598HPA063577SAB4300249
Anti-TFRC antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA028598

抗-TFRC 兔抗

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

mol wt

antigen ~90 kDa

mol wt

-

mol wt

-

mol wt

~72 kDa

一般描述

Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.

免疫原

synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH

应用

Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化/生理作用

Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.

外形

solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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1.6 Mb deletion in chromosome band 3q29 associated with eye abnormalities
Tyshchenko N, et al.
European Journal of Medical Genetics, 52(2-3), 128-130 (2009)
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas
Mando C, et al.
Placenta, 32(1), 44-50 (2011)
Peina Wang et al.
Antioxidants (Basel, Switzerland), 11(7) (2022-07-28)
Blood-brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following cerebral ischemia reperfusion (I/R) injury
Regulation of cellular iron metabolism
Wang J and Pantopoulos K
The Biochemical Journal, 434(3), 365-381 (2011)
Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells.
Gallego-Murillo, et al.
Scientific Reports, 13, 6960-6960 (2023)

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