Merck

SAB4200401

Sigma-Aldrich

Anti-CTGF antibody, Mouse monoclonal

clone CTGF-14, purified from hybridoma cell culture

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别名:
Monoclonal Anti-CCN family member 2, Monoclonal Anti-CCN2, Monoclonal Anti-CTGF antibody produced in mouse, Monoclonal Anti-Connective tissue growth factor, Monoclonal Anti-HCS24, Monoclonal Anti-Hypertrophic chondrocyte-specific protein 24, Monoclonal Anti-IBP-8, Monoclonal Anti-IGF-binding protein 8, Monoclonal Anti-IGFBP-8, Monoclonal Anti-IGFBP8, Monoclonal Anti-Insulin-like growth factor-binding protein 8, Monoclonal Anti-NOV2
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

CTGF-14, monoclonal

形式

buffered aqueous solution

分子量

antigen ~38 kDa

species reactivity

human

浓度

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): suitable
western blot: 0.25-0.5 μg/mL using whole extracts of HEK-293T cells over-expressing CTGF.

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... CTGF(1490)

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此商品
SAB4200473SAB4200360SAB4200416
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

CTGF-14, monoclonal

clone

4A7, monoclonal

clone

CYPB-3, monoclonal

clone

TN-17, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

antigen ~38 kDa

mol wt

antigen ~40 kDa

mol wt

antigen ~20 kDa

mol wt

antigen ~170 kDa

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一般描述

Monoclonal Anti-CTGF (mouse IgG1 isotype) is derived from the hybridoma CTGF-14 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Connective tissue growth factor (CTGF) gene is mapped to human chromosome 6q23.2. It encodes a splice variant and also known as CCN family member 2 (CCN2). CTGF belongs to the family of regulatory proteins of the extracellular matrix (ECM) and is secreted by endothelial cells. It is expressed in the embryonic stage. The domain regions associated with the CTGF comprise four modules namely: Insulin-like growth factor binding proteins module, von willebrand factor type C repeat, thrombospondin type I repeat and cystine knot associated carboxy-terminal domain.

特异性

Monoclonal Anti-CTGF recognizes human CTGF.

免疫原

immunized with a synthetic peptide corresponding to an internal region of human CTGF (GeneID: 1490), conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.

应用

Monoclonal Anti-CTGF antibody produced in mouse may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Connective tissue growth factor (CTGF) has been shown to play a role in developmental regulation of chondrogenesis, osteogenesis and angiogenesis, and in pathological processes, including fibrosis and tumorigenesis. CTGF may play an important role in the progression of malignant melanoma and the activation of wingless (WNT) signaling through low-density lipoprotein receptor-related protein 6 (LRP6). Certain polymorphisms in the CTGF gene have been linked with a higher incidence of systemic sclerosis.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze at -20oC in working aliquots. Repeated freezingand thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Yasaman Ramazani et al.
Matrix biology : journal of the International Society for Matrix Biology, 68-69, 44-66 (2018-03-27)
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.
Diego Pinheiro Aguiar et al.
Cancer cell international, 14, 61-61 (2014-08-15)
Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial
Brian Rooney et al.
FEBS letters, 585(3), 531-538 (2011-01-18)
We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF activity and expression of Wnt targets. This is coincident with decreased phosphorylation
Carmen Fonseca et al.
The New England journal of medicine, 357(12), 1210-1220 (2007-09-21)
Systemic sclerosis (scleroderma) is a life-threatening autoimmune disease that is characterized by the presence of specific autoantibodies and fibrosis of the skin and major internal organs. We genotyped a polymorphism (G-945C) in the promoter of the connective-tissue growth factor (CTGF)
S Braig et al.
British journal of cancer, 105(2), 231-238 (2011-06-16)
Malignant melanoma cells are known to have altered expression of growth factors compared with normal human melanocytes. These changes most likely favour tumour growth and progression, and influence tumour environment. The induction of transforming growth factor beta1, 2 and 3

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