Merck

SAB4200500

Sigma-Aldrich

抗-胶原IV抗体,小鼠单克隆

clone J3-2, purified from hybridoma cell culture

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别名:
单克隆抗-胶原蛋白IV 小鼠抗, 抗-COL4
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

J3-2, monoclonal

形式

buffered aqueous solution

species reactivity

mouse, rat, dog, bovine, human, monkey

浓度

~1.0 mg/mL

technique(s)

immunohistochemistry: 2.0-4.0 μg/mL using human liver tissue sections.
western blot: 1.0-2.0 μg/mL using human placenta extracts.

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL4A1(1282)

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此商品
C1926SAB4200709SAB4200678
conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

clone

J3-2, monoclonal

clone

COL-94, monoclonal

clone

col-94, monoclonal

clone

COL-1, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

mouse, rat, dog, bovine, human, monkey

species reactivity

human

species reactivity

monkey, human

species reactivity

pig, rat, human, deer, bovine

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一般描述

人胶原IV包含六个基因。COL4A1-COL4A2定位于13号染色体。COL4A3-COL4A4和COL4A5-COL4A6分别位于2号染色体和X号染色体上。它属于胶原超家族,并与基底膜(BMs)相关。六个α链,即α1(IV)至α6(IV)包含N端半胱氨酸和赖氨酸结构域,典型的Gly-X-Y三重重复序列和C端非胶原(NC1)结构域。

免疫原

胎盘制剂富含基底膜胶原蛋白。

应用

小鼠抗IV型胶原单克隆抗体可用于:
  • 免疫组织化学染色
  • 免疫染色
  • 免疫荧光检测
  • 作为免疫印迹分析的二抗

生化/生理作用

胶原蛋白IV在基底膜组装中起关键作用。六个链组装成三个不同的原体,即α 1.α1.α2(IV)、α3.α4.α5(IV)和α 5.α5.α6(IV)。三聚体以α-链的不同组合形成。在专门的肾小球BM(GBM)中观察到α3、α4和α5的高表达水平。COlA5基因的突变与Alport综合征有关,而α3(IV)链与Goodpasture综合征(一种自身免疫性疾病)的发病机制有关。COlA5中的突变也与弥漫性食管平滑肌瘤病有关。

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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