Merck

SAB4200670

Sigma-Aldrich

抗肌球蛋白(骨骼肌慢肌)抗体,小鼠单克隆

clone NOQ7.5.4D, purified from hybridoma cell culture

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别名:
CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

NOQ7.5.4D, monoclonal

形式

buffered aqueous solution

species reactivity

sheep, goat, chicken, feline, guinea pig, pig, rabbit, hamster, canine, rat, human, mouse, bovine

包装

antibody small pack of 25 μL

浓度

~1 mg/mL

technique(s)

immunoblotting: 1.25-2.5 μg/mL using Rat skeletal muscle lysate.
immunohistochemistry: 2.5-5 μg/mL using pronase digested, formalin-fixed, paraffin-embedded rabbit tongue/leg sections and Biotin/ExtrAvidin®-Peroxidase staining system.

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYH7(4625)

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此商品
M8421M4276M1570
antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

purified immunoglobulin

clone

NOQ7.5.4D, monoclonal

clone

NOQ7.5.4D, monoclonal

clone

MY-32, monoclonal

clone

MY-32, monoclonal

form

buffered aqueous solution

form

-

form

-

form

buffered aqueous solution

species reactivity

sheep, goat, chicken, feline, guinea pig, pig, rabbit, hamster, canine, rat, human, mouse, bovine

species reactivity

sheep, rat, bovine, hamster, pig, canine, feline, goat, chicken, mouse, rabbit, human, guinea pig

species reactivity

rat, chicken, rabbit, mouse, human, bovine, guinea pig, feline

species reactivity

rat, chicken, rabbit, mouse, human, bovine, guinea pig, feline

packaging

antibody small pack of 25 μL

packaging

antibody small pack of 25 μL

packaging

-

packaging

antibody small pack of 25 μL

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一般描述

单克隆抗肌球蛋白(骨骼肌,慢肌)(小鼠IgG1同种型)来源于小鼠骨髓瘤细胞和BALB / c小鼠脾细胞融合产生的NOQ7.5.4D杂交瘤。肌球蛋白是一种六聚体蛋白,包含两个重链亚基和四个轻链亚基。它是心脏和骨骼肌的主要蛋白质成分。肌肉肌球蛋白重链(MHC)的不同同种型根据肌肉的生理功能进行表达:骨骼、心脏、平滑和非肌肉。

免疫原

肌球蛋白,从人骨骼肌分离的肌原纤维中提纯,

应用

小鼠生产的单克隆抗肌球蛋白(骨骼肌,慢肌)抗体已被用于免疫印迹、免疫组织学、固相放射免疫测定(RIA)、酶联免疫吸附测定(ELISA)和免疫电镜检查。

生化/生理作用

肌球蛋白是肌动蛋白依赖性马达。肌球蛋白基因突变与肌病、失明和听力损失有关。它们参与肌肉收缩、视觉、听觉、细胞运动和细胞侵袭。
肌球蛋白负责心脏和骨骼肌的能量传导和力量发展(force development)。现已确知肌球蛋白可与肌肉和非肌肉细胞中的肌动蛋白相互作用。慢肌球蛋白,也称β-肌球蛋白重链(β-MHC),在胚胎发生过程中表达,它是心脏生肌程序(cardiac myogenic program)的一部分,受到NK-2同源框蛋白5(NKX-2.5)、肌细胞增强因子2C(MEF- 2C)和GATA-4 / 5/6的控制。

外形

溶于 0.01 M 磷酸盐缓冲液 (pH 7.4) 中,含 15 mM 叠氮化钠 e。

法律信息

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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