Merck

SAB4200690

Sigma-Aldrich

Anti-EpCAM antibody, Mouse monoclonal

clone Ber-EP4, hybridoma cell culture supernatant

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别名:
Anti-CD326 antigen, Anti-EGP, Anti-Epithelial cell surface antigen, Anti-Epithelial glycoprotein, Anti-KS 1/4 antigen, Anti-KSA, Anti-Major gastrointestinal tumor-associated protein GA733-2, Anti-Tumor-associated calcium signal transducer 1

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

culture supernatant

antibody product type

primary antibodies

克隆

Ber-EP4, monoclonal

形式

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: 1:500-1:1,000 using human breast adenocarcinoma MCF-7 cell line.
immunohistochemistry: 1:250-1:500 using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.
immunoprecipitation (IP): suitable

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... EPCAM(4072)

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此商品
SAB4200704SAB4700423SAB4700425
conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

phycoerythrin (R-PE) conjugate

antibody form

culture supernatant

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

Ber-EP4, monoclonal

clone

Ber-EP4, monoclonal

clone

VU-1D9, monoclonal

clone

VU-1D9, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

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一般描述

Anti-EpCAM antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma Ber-EP4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human breast carcinoma cell line MCF-7. EpCAM (Epithelial cell adhesion molecule) is a highly conserved type I transmembrane glycoprotein. EpCAM is present on most epithelia tissues of the adult body and in undifferentiated rather than differentiated embryonic stem cells.

免疫原

human breast carcinoma cell line MCF-7

应用

Anti-EpCAM antibody has been used in:
  • immunofluorescence
  • immunohistochemistry
  • immunoprecipitation

生化/生理作用

EpCAM (Epithelial cell adhesion molecule) regulates cell-cell contact adhesion strength and tissue plasticity and epithelial cell proliferation and differentiation. Mutations in EpCAM are associated with several intestinal abnormalities such as Lynch syndrome, and congenital tufting enteropathy (CTE). Anti-EpCAM has been proved valuable for the distinction of undifferentiated primary or metastatic tumors from non-epithelial tumors, bile duct cells from hepatocytes in certain liver diseases, and between epithelial and normal reactive or neoplastic mesothelial cells from carcinoma cells.

外形

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
Kempers MJE, et al.
Lancet Oncology, 12(1), 49-55 (2011)
The emerging role of EpCAM in cancer and stem cell signaling
Munz M, et al.
Cancer Research, 69(14), 5627-5629 (2009)
Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule
Trzpis M, et al.
The American Journal of Pathology, 171(2), 386-395 (2007)
Identification of EpCAM as the gene for congenital tufting enteropathy
Sivagnanam M, et al.
Gastroenterology, 135(2), 429-437 (2008)
Ming Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 6103-6113 (2020-03-04)
Clinical observation of the association between cancer aggressiveness and embryonic development stage implies the importance of developmental signals in cancer initiation and therapeutic resistance. However, the dynamic gene expression during organogenesis and the master oncofetal drivers are still unclear, which

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