Merck

SAB4200704

Sigma-Aldrich

Anti-EpCAM antibody, Mouse monoclonal

clone Ber-EP4, purified from hybridoma cell culture

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别名:
Anti-CD326 antigen, Anti-EGP, Anti-Epithelial cell surface antigen, Anti-Epithelial glycoprotein, Anti-KS 1/4 antigen, Anti-KSA, Anti-Major gastrointestinal tumor-associated protein GA733-2, Anti-Tumor-associated calcium signal transducer 1
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

Ber-EP4, monoclonal

形式

buffered aqueous solution

species reactivity

human

浓度

~1 mg/mL

technique(s)

immunofluorescence: 1-2 μg/mL using human breast adenocarcinoma MCF-7 cell line.
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.
immunoprecipitation (IP): suitable

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... EPCAM(4072)

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此商品
SAB4200473SAB4200690MABT1587
antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

culture supernatant

antibody form

purified antibody

clone

Ber-EP4, monoclonal

clone

4A7, monoclonal

clone

Ber-EP4, monoclonal

clone

EpMab?16, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

-

species reactivity

human

species reactivity

human, mouse

species reactivity

human

species reactivity

human

concentration

~1 mg/mL

concentration

~1.0 mg/mL

concentration

-

concentration

-

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一般描述

The epithelial cell adhesion molecule (EpCAM) is mapped to human chromosome 2p21 and has nine exons. EpCAM is a 40 kDa transmembrane glycoprotein present on cell surface. It has an intracellular domain called the EpICD, comprising of 26-amino acids. The extracellular domain (EpEX) has an epidermal growth factor (EGF) and a thyroglobulin repeat-like domain.

免疫原

human breast carcinoma cell line MCF-7

生化/生理作用

The epithelial cell adhesion molecule (EpCAM) is highly expressed in carcinomas. It regulates cell signalling, proliferation, migration and adhesion. Proteolytic cleavage of EpICD domain is crucial for tumor progression. EpCAM is highly expressed in breast cancer and is considered as a potential target for gene therapy. Deletions in the 3′ region of the EpCAM gene is associated with colorectal cancer based lynch syndrome. Single nucleotide polymorphism in EpCAM gene is associated with infant diarrheal disorder, congenital tufting enteropathy(CTE).

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
Osta WA, et al.
Cancer Research, 64(16), 5818-5824 (2004)
Nadim Aizarani et al.
Nature, 572(7768), 199-204 (2019-07-12)
The human liver is an essential multifunctional organ. The incidence of liver diseases is rising and there are limited treatment options. However, the cellular composition of the liver remains poorly understood. Here we performed single-cell RNA sequencing of about 10,000
M V Apte et al.
Gut, 43(1), 128-133 (1998-10-15)
The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells (vitamin A storing cells) play a significant role in the development of fibrosis. To determine whether cells resembling hepatic stellate cells are present in rat pancreas, and if
EpCAM in carcinogenesis: the good, the bad or the ugly
van der Gun BT, et al.
Carcinogenesis, 31(11), 1913-1921 (2010)
Identification of EpCAM as the gene for congenital tufting enteropathy
Sivagnanam M, et al.
Gastroenterology, 135(2), 429-437 (2008)

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