Merck
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SAB4200721

Sigma-Aldrich

抗-GABA抗体,小鼠单克隆

clone GB-69, purified from hybridoma cell culture

Synonym(s):
Mouse Anti-Gamma-aminobutyric acid
NACRES:
NA.41

生物来源

mouse

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

GB-69, monoclonal

形式

buffered aqueous solution

species reactivity

rat, monkey, frog, mouse, human, gerbil

浓度

~1.0 mg/mL

technique(s)

ELISA: suitable
dot blot: suitable
immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line
immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

Gene Information

human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)

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ABN131G2791SAB4200783
Anti-GABA Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABN131

抗-GABA抗体

biological source

mouse

biological source

rabbit

biological source

mouse

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

GB-69, monoclonal

clone

polyclonal

clone

GRB-232, monoclonal

clone

HP-6014, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

rat, monkey, frog, mouse, human, gerbil

species reactivity

rat

species reactivity

rat, mouse, human

species reactivity

human

concentration

~1.0 mg/mL

concentration

-

concentration

~2 mg/mL

concentration

~1.0 mg/mL

一般描述

小鼠单克隆抗GABA抗体(小鼠IgG1同种型)来源于小鼠骨髓瘤细胞与纯化BSA偶联GABA免疫的小鼠脾细胞融合产生的GB-69 杂交瘤。γ-氨基丁酸(GABA)存在于脊椎动物的中枢神经系统(CNS)中。谷氨酸脱羧酶(GAD)催化L-谷氨酸的酶促脱羧反应,形成GABA。

免疫原

与BSA偶联的纯化的GABA

应用

小鼠单克隆抗GABA抗体已被用于:
  • 免疫荧光
  • 免疫组织化学
  • 酶链免疫吸附检测 (ELISA)
  • 斑点印迹

生化/生理作用

γ-氨基丁酸(GABA)是主要的抑制性神经递质。GABA介导快速的中枢神经系统突触抑制,并作为感觉回路在功能发育中起关键作用。GABA促进免疫细胞、胚胎干细胞和皮质祖细胞的增生。此外,它还涉及蛋白质合成和代谢,并在肌肉张力、血压、心率和呼吸的调节中起重要作用。

外形

0.01 M 磷酸盐缓冲液 (pH 7.4) 中的溶液,含 15 mM 叠氮化钠

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途,或人类或动物任何类型的消费或使用。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


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